Nelfinavir Mesylate

製品コードS4282 バッチS428204

化学情報

	Synonyms	AG 1343 Mesylate	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₃₃H₄₉N₃O₇S₂
	分子量	663.89	CAS No.	159989-65-8
Solubility (25°C)*	体外	DMSO	100 mg/mL (150.62 mM)
		Ethanol	100 mg/mL (150.62 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Nelfinavir Mesylate is a potent HIV protease inhibitor with K_i of 2 nM.
in vivo	In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. Initial investigation of the compound in fed rats indicated an oral bioavailability of 43%. In contrast, the oral bioavailability was significantly reduced in fasted rats to 29%. Nelfinavir demonstrated significant oral bioavailabilability across a range of species including dogs (47%), marmosets (17%), and cynomolgus monkeys (26%). It has a long plasma half-life after oral dosing that is likely due to a combination of slow dissolution and absorption. nelfinavir is well absorbed in humans particularly when administered with food and possesses minimal and easily managed side effects^[1].

製品説明

Nelfinavir Mesylate is a potent HIV protease inhibitor with K_i of 2 nM.

in vivo

In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. Initial investigation of the compound in fed rats indicated an oral bioavailability of 43%. In contrast, the oral bioavailability was significantly reduced in fasted rats to 29%. Nelfinavir demonstrated significant oral bioavailabilability across a range of species including dogs (47%), marmosets (17%), and cynomolgus monkeys (26%). It has a long plasma half-life after oral dosing that is likely due to a combination of slow dissolution and absorption. nelfinavir is well absorbed in humans particularly when administered with food and possesses minimal and easily managed side effects^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague-Dawley rats
	投薬量	12.5 to 25 mg/kg (i.v); 25 to 50 mg/kg (oral)
	投与方法	i.v and oral administration

参考

[1] Kaldor SW, et al.J Med Chem, 1997,40(24):3979-85.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir [ Int J Mol Sci, 2023, 24(7)6062]	PubMed: 37047038
Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir [ Int. J. Mol. Sci, 2023, 10.3390/ijms24076062]	PubMed: None
Co-administration of Favipiravir and the Remdesivir Metabolite GS-441524 Effectively Reduces SARS-CoV-2 Replication in the Lungs of the Syrian Hamster Model [ mBio, 2022, 13(1):e0304421]	PubMed: 35100870
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients [ J Cell Biochem, 2022, 10.1002/jcb.30213]	PubMed: 35037717
Aspartyl Protease Inhibitors as Anti-Filarial Drugs [ Pathogens, 2022, 11(6)707]	PubMed: 35745561
Drug target inference by mining transcriptional data using a novel graph convolutional network framework [ Protein Cell, 2021, 10.1007/s13238-021-00885-0]	PubMed: 34677780
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening [ Cell Rep, 2021, 35(10):109218]	PubMed: 34038715
Multiple Myeloma Cells Depend on the DDI2/NRF1-mediated Proteasome Stress Response for Survival [ Blood Adv, 2021, bloodadvances.2020003820]	PubMed: 34649278
Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening [ Sci Rep, 2021, 11(1):19443]	PubMed: 34593846
Prevention of SARS-CoV-2 Proliferation with a Novel and Potent Main Protease Inhibitor by Docking, ADMET, MM-PBSA, and Molecular Dynamics Simulation [ World Scientific, 2021, Vol. 20, No. 03, pp. 305-322]	PubMed: None

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。