受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C11H15ClN2O5 |
|||
分子量 | 290.7 | CAS No. | 23111-00-4 | |
Solubility (25°C)* | 体外 | DMSO | 58 mg/mL (199.51 mM) | |
Water | 58 mg/mL (199.51 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements. |
---|---|
in vitro | Nicotinamide Riboside supplementation increases NAD+ content and sirtuin activity in cultured mammalian cells.[1] |
in vivo | Nicotinamide Riboside, a precursor to nicotinamide adenine dinucleotide(NAD), restores tissue NAD+ depletion induced by acute kidney injury (AKI) to that of the sham group, increases autophagy and sirtuin1 (Sirt1).[2] |
細胞アッセイ | 細胞株 | C2C12 myotubes, Hepa1.6 and HEK293T cells |
---|---|---|
濃度 | 0-1000 μM | |
反応時間 | 24 h | |
実験の流れ | -- |
|
動物実験 | 動物モデル | Two-month-old male Wistar rats |
投薬量 | 500 g/kg/day | |
投与方法 | o.g. |
|
Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation [ Front Physiol, 2023, 14:1164287] | PubMed: 37650111 |
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming [ Cell Discov, 2022, 8(1):106] | PubMed: 36220812 |
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation [ Cell Death Differ, 2022, 10.1038/s41418-022-00992-3] | PubMed: 35568718 |
Aberrant NAD+ metabolism underlies Zika virus-induced microcephaly [ Nat Metab, 2021, 3(8):1109-1124] | PubMed: 34385701 |
Effect of NAD+ boosting on kidney ischemia-reperfusion injury [ PLoS One, 2021, 16(6):e0252554] | PubMed: 34061900 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。