Nintedanib Ethanesulfonate Salt

製品コードS5234 バッチS523405

印刷

化学情報

Synonyms

Intedanib, BIBF 1120

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₃₁H₃₃N₅O₄.C₂H₆O₃S

分子量

649.76

CAS No.

656247-18-6

Solubility (25°C)*

体外

DMSO

100 mg/mL (153.9 mM)

Water

20 mg/mL (30.78 mM)

Ethanol

3 mg/mL (4.61 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/18559524/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Antineoplastic efficacy profiles of avapritinib and nintedanib in KIT D816V+ systemic mastocytosis: a preclinical study [ Am J Cancer Res, 2023, 13(2):355-378]	PubMed: 36895976
Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells [ Theranostics, 2022, 12(2):747-766]	PubMed: 34976211
Blockade of the pro-fibrotic reaction mediated by the miR-143/-145 cluster enhances the responses to targeted therapy in melanoma [ EMBO Mol Med, 2022, 14(3):e15295]	PubMed: 35156321
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma [ Cell Death Dis, 2022, 13(8):711]	PubMed: 35974000
Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence [ Biomolecules, 2022, 12(5)734]	PubMed: 35625661
Beovu, but not Lucentis impairs the function of the barrier formed by retinal endothelial cells in vitro [ Sci Rep, 2022, 12(1):12493]	PubMed: 35864147
Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients [ Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344]	PubMed: 36066384
Contracting scars from fibrin drops [ Integr Biol (Camb), 2022, 14(1):1-12]	PubMed: 35184163
Targeting fibroblast growth factor receptors to combat aggressive ependymoma [ Acta Neuropathol, 2021, 10.1007/s00401-021-02327-x]	PubMed: 34046693

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。