NMDA (N-Methyl-D-aspartic acid)

製品コードS7072 バッチS707203

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₅H₉NO₄

分子量

147.13

CAS No.

6384-92-5

Solubility (25°C)*

体外

Water

29 mg/mL (197.1 mM)

DMSO

15 mg/mL (101.95 mM)

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

	5% DMSO 1 95% Corn oil	0.75mg/ml
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	0.75mg/ml

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
in vitro	NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca²⁺ and Na⁺ into the cell and K⁺ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca²⁺ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). ^[1]

製品説明

NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

in vitro

NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca²⁺ and Na⁺ into the cell and K⁺ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca²⁺ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). ^[1]

プロトコル(参考用のみ)

参考

[1] Cull-Candy S, et al. Curr Opin Neurobiol, 2001, 11(3), 327-335.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress [ CNS Neurosci Ther, 2024, 30(2):e14611]	PubMed: 38353051
The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor-CaMKII pathway [ Open Life Sci, 2024, 19(1):20220816]	PubMed: 38314140
Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus [ Aging -Albany NY), 2023, 15(12):5698-5712]	PubMed: 37348034
Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus [ Aging (Albany NY), 2023, 15(12):5698-5712]	PubMed: 37348034
Magnesium Oxide/Poly (L-lactide-co-ε-caprolactone) Scaffolds Loaded with Neural Morphogens Promote Spinal Cord Repair through Targeting the Calcium Influx and Neuronal Differentiation of Neural Stem Cells [ Adv Healthc Mater, 2022, e2200386]	PubMed: 35587044
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability [ Fluids Barriers CNS, 2022, 19(1):70]	PubMed: 36068542
N-Methyl D-aspartate receptor subtype 2B/Ca2+/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia [ Front Cell Neurosci, 2022, 16:981190]	PubMed: 36187288
NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation. [ Mol Brain, 2018, 11(1):35]	PubMed: 29954440

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。