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Synonyms | Arterenol, Levarterenol, L-Noradrenaline | Storage (From the date of receipt) |
3 years -20°C(in the dark) powder 1 year -80°C(in the dark) in solvent |
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化学式 | C8H11NO3 |
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分子量 | 169.18 | CAS No. | 51-41-2 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 11 mg/mL (65.01 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. |
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in vitro | (-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2] |
in vivo | Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3] |
細胞アッセイ | 細胞株 | MH-S murine alveolar macrophage cells |
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濃度 | 0.01μM, 0.1μM, 1 μM | |
反応時間 | ||
実験の流れ | After plating on to 48-well plates (2×105 cells/well), MH-S cells are stimulated with LPS (10 ng/ml) for 6, 12, 18, or 24 h to select the optimum exposure length. In the second step, cells are incubated with norepinephrine (0, 0.01, 0.1, or 1 μM) for 30min and then incubated with or without LPS (10ng/ml) for 6h. In the third step, cells are pre-incubated with BRL (0, 2, 5, or 10 μM) for 30 min and treated with norepinephrine (1 μM) or PBS for a further 30 min, then stimulated with LPS (10 ng/ml) or maintained in PBS for 6 h. The cell culture supernatant is collected and stored at 80 C for cytokine detection. Total protein is extracted from cells for Western blot analysis. The cytotoxicity of norepinephrine, BRL, and LPS to MH-S cells are measured by CCK-8. |
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動物実験 | 動物モデル | Senescence-accelerated prone 8 (SAMP8) mice, senescence-resistant 1 (SAMR1) mice |
投薬量 | 10 μM (2 μL) | |
投与方法 | i.c.v. |
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Generation of self-organized autonomic ganglion organoids from fibroblasts [ iScience, 2023, 26(3):106241] | PubMed: 36922996 |
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice [ Commun Biol, 2022, 5(1):339] | PubMed: 35396348 |
Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes [ Eur J Pharmacol, 2022, 926:175040] | PubMed: 35598846 |
α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome [ Clin Sci (Lond), 2020, 134(14):1957-1971] | PubMed: 32643759 |
Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway [ Cardiovasc Drugs Ther, 2020, 11] | PubMed: 32394178 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。