NQDI-1

製品コードS8289 バッチS828901

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C19H13NO4
分子量 319.31 CAS No. 175026-96-7
Solubility (25°C)* 体外 DMSO 21 mg/mL (65.76 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
in vivo NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1[1].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 MEFs
濃度 10 μM, 30 μM and 50 μM 
反応時間
実験の流れ
動物実験 動物モデル Female Sprague-Dawley rats
投薬量 250 nmol
投与方法 intracerebroventricularly

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response [ Redox Biol, 2023, 60:102618] PubMed: 36724577
Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway [ J Neuroinflammation, 2023, 20(1):22] PubMed: 36737785
ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats [ Mol Med Rep, 2023, 27(2)47] PubMed: 36633130
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma [ Cell Death Dis, 2022, 13(3):197] PubMed: 35236820
A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells [ Arterioscler Thromb Vasc Biol, 2022, 42(5):580-596] PubMed: 35387478
Chronic-plus-binge Alcohol Intake Induces Production of Proinflammatory mtDNA-enriched Extracellular Vesicles and Steatohepatitis via ASK1-p38MAPKα-dependent Mechanisms [ JCI Insight, 2020, 136496] PubMed: 32544093
Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain. [ J Neuroinflammation, 2019, 16(1):83] PubMed: 30975172
The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma. [ Int J Cancer, 2019, 10.1002/ijc.32615] PubMed: 31390487
Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen [Wang X J Steroid Biochem Mol Biol, 2019, 187:166-173] PubMed: 30508644
ASK1 induces retinal microvascular endothelial cell apoptosis through ER stress-associated pathway [ Int J Clin Exp Pathol, 2019, 12(4):1324-1332] PubMed: 31933946

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。