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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C38H40N10 |
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分子量 | 636.79 | CAS No. | 81624-55-7 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (157.03 mM) | |
Ethanol | 100 mg/mL (157.03 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM. |
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in vitro | NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53 and induces apoptosis[1]. |
in vivo | In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration.[2]. |
細胞アッセイ | 細胞株 | LNCaP cells/Granta cells |
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濃度 | 0.01–60 μM for LNCaP cells; 0.5–2.8 μM for Granta cells | |
反応時間 | ||
実験の流れ | ||
動物実験 | 動物モデル | Mice bearing either orthotopic MDA-MB-231-GFP tumors (MDA231) or patient-derived HT17 and HT19 tumors |
投薬量 | 25 mg/kg | |
投与方法 | i.p. |
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NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer. [ Nat Commun, 2020, 3;11(1):1669] | PubMed: 32245950 |
Nucleolar protein NPM1 is essential for circovirus replication by binding to viral capsid [ Virulence, 2020, 11(1):1379-1393] | PubMed: 33073687 |
Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization [ Reproduction, 2020, 160(4):491-500] | PubMed: 32817586 |
Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines. [ Cell Death Dis, 2019, 10(11):831] | PubMed: 31685803 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。