Oleuropein

製品コードS7867 バッチS786702

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₅H₃₂O₁₃

分子量

540.51

CAS No.

32619-42-4

Solubility (25°C)*

体外

DMSO

100 mg/mL (185.01 mM)

Ethanol (warmed with 50ºC water bath)

100 mg/mL (185.01 mM)

Water (warmed with 50ºC water bath)

50 mg/mL (92.5 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.
in vitro	In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. ^[1] This compound prevents oxidative myocardial injury induced by ischemia and reperfusion. ^[2] In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, it inhibits cell proliferation and migration. ^[3]
in vivo	In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. ^[3] In rats, this compound (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity. ^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells
	濃度	--
	反応時間	5 days
	実験の流れ	Approximately 5 × 10³ cells (TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib) are seeded in triplicate wells of 96-well plates in 100 μl of their respective growth medium with increasing doses of purified Oleuropein. Cell proliferation is determined on day 5 using the CellTiter MTS cell proliferation kit according to the manufacturer’s instructions. Absorbance at 490 nm is measured with a Bio-Tek Instruments microplate reader. Background readings are subtracted from the experimental readings.
動物実験	動物モデル	Swiss albino mice that spontaneously develops soft tissue sarcomas
	投薬量	50 μg/mouse
	投与方法	i.p. or p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/9464466/
https://pubmed.ncbi.nlm.nih.gov/15302080/
https://pubmed.ncbi.nlm.nih.gov/16024000/

https://pubmed.ncbi.nlm.nih.gov/26056852/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Transcriptome profiling reveals superovulation with the gonadotropin-releasing hormone agonist trigger impaired embryo implantation in mice [ Front Endocrinol (Lausanne), 2024, 15:1354435]	PubMed: 38469140
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447]	PubMed: 30900754

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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