Olodaterol

製品コードS4485 バッチS448501

印刷

化学情報

Synonyms

BI 1744

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₂₁H₂₆N₂O₅

分子量

386.44

CAS No.

868049-49-4

Solubility (25°C)*

体外

DMSO

77 mg/mL (199.25 mM)

Ethanol

40 mg/mL (103.5 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	3.850mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 77 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.550mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).
in vivo	The bronchoprotective half-life of abediterol in guinea pigs is 47 h for olodaterol. In anaesthetised dogs, this compound inhibits acetylcholine-induced bronchoconstriction, with ID40 (dose inhibiting bronchoconstriction by 40%) of 0.180 µg/kg. In parallel, effect on heart rate in dogs is measured, showing a safety index (defined as the ratio of the maximal dose without effect on heart rate and the ID40) of 10.5.^[2]

製品説明

Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).

in vivo

The bronchoprotective half-life of abediterol in guinea pigs is 47 h for olodaterol. In anaesthetised dogs, this compound inhibits acetylcholine-induced bronchoconstriction, with ID40 (dose inhibiting bronchoconstriction by 40%) of 0.180 µg/kg. In parallel, effect on heart rate in dogs is measured, showing a safety index (defined as the ratio of the maximal dose without effect on heart rate and the ID40) of 10.5.^[2]

プロトコル(参考用のみ)

動物実験	動物モデル	guinea pigs (bodyweight 340–580 g); male Beagle dogs
	投薬量	0.03, 0.1, 0.3, 3, 10 and 30 mg/ml for guinea pigs; 0.1, 1, and 10 mg/kg for dogs
	投与方法	aerosolised; respiratory pump

参考

https://pubmed.ncbi.nlm.nih.gov/31119643/
https://pubmed.ncbi.nlm.nih.gov/26656755/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。