受注:045-509-1970 |
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Synonyms | RP 35972, NSC 347901 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C8H6N2S3 |
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分子量 | 226.34 | CAS No. | 64224-21-1 | |
Solubility (25°C)* | 体外 | DMSO | 39 mg/mL warmed with 50ºC water bath (172.3 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3. |
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in vitro | Oltipraz, as a chemoprotective agent, induces Phase II detoxification enzyme activity in a Nrf2-dependent manner. [1] In human HT29 colon cancer cells, oltipraz inhibits the induction of HIF-1α by insulin, hypoxia or CoCl2 by significantly accelerating degradation of HIF-1α protein. [2] |
in vivo | Oltipraz (500 mg/kg, p.o.) significantly reduces multiplicity of gastric neoplasia in wild-type mice by 55%, but has no effect on tumor burden in nrf2-deficient mice. [1] In BALB/c nude mice transplanted with HCT116 cells, Oltipraz (200 mg/kg, p.o.) inhibits tumor growth and angiogenesis via inhibition of HIF-1α. [2] In rats on a CDAA diet, Oltipraz attenuate the progression of nonalcoholic steatohepatitis-related fibrosis. [3] |
動物実験 | 動物モデル | Female wild-type and nrf2-disrupted mice |
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投薬量 | 500 mg/kg | |
投与方法 | p.o. |
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, , Arch Toxicol, 2017, 92(2):679-692
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression [ J Neuroinflammation, 2023, 20(1):212] | PubMed: 37735410 |
Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis [ PLoS Genet, 2022, 18(3):e1010128] | PubMed: 35294432 |
Berberine attenuates the inflammatory response by activating the Keap1/Nrf2 signaling pathway in bovine endometrial epithelial cells [ Int Immunopharmacol, 2021, 96:107738] | PubMed: 33984720 |
Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis. [ Biomaterials, 2019, 219:119368] | PubMed: 31349200 |
Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. [ Free Radic Biol Med, 2019, 137:1-12] | PubMed: 31004750 |
Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation [Wang X Inflammation, 2018, 41(3):948-958] | PubMed: 29549478 |
P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway. [Han D, et al. Arch Toxicol, 2017, 10.1007/s00204-017-2070-2] | PubMed: 28940008 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。