Oltipraz

製品コードS7864 バッチS786403

印刷

化学情報

Chemical Structure Synonyms RP 35972, NSC 347901 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C8H6N2S3
分子量 226.34 CAS No. 64224-21-1
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 23 mg/mL (101.61 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.
in vitro Oltipraz, as a chemoprotective agent, induces Phase II detoxification enzyme activity in a Nrf2-dependent manner. [1] In human HT29 colon cancer cells, this compound inhibits the induction of HIF-1α by insulin, hypoxia or CoCl2 by significantly accelerating degradation of HIF-1α protein. [2]
in vivo Oltipraz (500 mg/kg, p.o.) significantly reduces multiplicity of gastric neoplasia in wild-type mice by 55%, but has no effect on tumor burden in nrf2-deficient mice. [1] In BALB/c nude mice transplanted with HCT116 cells, this compound (200 mg/kg, p.o.) inhibits tumor growth and angiogenesis via inhibition of HIF-1α. [2] In rats on a CDAA diet, it attenuates the progression of nonalcoholic steatohepatitis-related fibrosis. [3]

プロトコル(参考用のみ)

動物実験 動物モデル Female wild-type and nrf2-disrupted mice
投薬量 500 mg/kg
投与方法 p.o.

参考

  • https://pubmed.ncbi.nlm.nih.gov/11248092/
  • https://pubmed.ncbi.nlm.nih.gov/19789218/
  • https://pubmed.ncbi.nlm.nih.gov/23592516/

カスタマーフィードバック

, , Arch Toxicol, 2017, 92(2):679-692

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Berberine inhibits LPS-induced epithelial-mesenchymal transformation by activating the Nrf2 signalling pathway in bovine endometrial epithelial cells [ Int Immunopharmacol, 2024, 143(Pt 1):113346] PubMed: 39393271
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression [ J Neuroinflammation, 2023, 20(1):212] PubMed: 37735410
Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis [ PLoS Genet, 2022, 18(3):e1010128] PubMed: 35294432
Berberine attenuates the inflammatory response by activating the Keap1/Nrf2 signaling pathway in bovine endometrial epithelial cells [ Int Immunopharmacol, 2021, 96:107738] PubMed: 33984720
Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis. [ Biomaterials, 2019, 219:119368] PubMed: 31349200
Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. [ Free Radic Biol Med, 2019, 137:1-12] PubMed: 31004750
Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation [Wang X Inflammation, 2018, 41(3):948-958] PubMed: 29549478
P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway. [Han D, et al. Arch Toxicol, 2017, 10.1007/s00204-017-2070-2] PubMed: 28940008

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。