OSS_128167

製品コードS8627 バッチS862701

印刷

化学情報

Synonyms

SIRT6-IN-1

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₉H₁₄N₂O₆

分子量

366.32

CAS No.

887686-02-4

Solubility (25°C)*

体外

DMSO

73 mg/mL (199.27 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	OSS_128167 (SIRT6-IN-1)は、SIRT6、SIRT1、SIRT2に対しそれぞれ89、1578、751 μMのIC50値を持つ、特異的なSIRT6阻害剤です。OSS_128167はHBVの転写と複製において抗ウイルス効果を示します。
in vitro	OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. This compound increases H3K9 acetylation and GLUT-1 expression.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BxPC3 cells
	濃度	100 μM
	反応時間	0, 2, 6, 18, 24 h
	実験の流れ	4 × 10⁵ BxPC3 cells are plated in six-well plates and allowed to adhere for 24 h. Thereafter, cells are stimulated with 100 μM OSS-128167 or the respective amounts of vehicle DMSO for the indicated time amounts. Finally, cells are used for protein lysate generation, and total H3 and acetylated H3K9 levels are detected by immunoblotting.

参考

https://pubmed.ncbi.nlm.nih.gov/24785705/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production [ Front Immunol, 2024, 15:1402834]	PubMed: 39253083
[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6 [ Sci Rep, 2024, 14(1):30924]	PubMed: 39730568
Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery [ Antioxidants (Basel), 2023, 12(3)714]	PubMed: 36978961
Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury via SIRT6-Mediated Autophagy Activation [ Oxid Med Cell Longev, 2022, 2022:9035547]	PubMed: 36160707
SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart [ Cell Biol Toxicol, 2022, 10.1007/s10565-022-09735-z]	PubMed: 35798905
Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress [ Biochem Pharmacol, 2022, 199:115022]	PubMed: 35358477
Downregulation of Sirt6 by CD38 promotes cell senescence and aging [ Aging (Albany NY), 2022, 14(23):9730-9757]	PubMed: 36490326
Deacetylation of ATG4B promotes autophagy initiation under starvation [ Sci Adv, 2022, 8(31):eabo0412]	PubMed: 35921421
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1 [ NPJ Precis Oncol, 2021, 5(1):20]	PubMed: 33742100
SIRT6 Maintains Redox Homeostasis to Promote Porcine Oocyte Maturation [ Front Cell Dev Biol, 2021, 9:625540]	PubMed: 33718364

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。