p-Coumaric Acid

製品コードS4759 バッチS475901

化学情報

	Synonyms	4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₉H₈O₃
	分子量	164.16	CAS No.	501-98-4
Solubility (25°C)*	体外	DMSO	32 mg/mL (194.93 mM)
		Ethanol	32 mg/mL (194.93 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.
in vitro	p-Coumaric acid is the most abundant isomer in natureand is biosynthesized from cinnamic acid by the action ofthe P450-dependent enzyme 4-cinnamic acid hydroxylase. p-Coumaric acid possesses antioxidant properties that reduce the risk of stomachcancer by suppressing the formation of carcinogenic nitrosamines. p-coumaric acid effectively suppressed endo-thelial cell migration, tube formation, and rat aorta ring sprouting. It reduces intracellular andmitochondrial reactive oxygen species production^[1].
in vivo	p-coumaric acid signif-icantly suppressed tumor growth in vivo by blockingangiogenesis^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	ECV304 cells
	濃度	0-5 mM
	反応時間	24 h
	実験の流れ	ECV304 cells were seededat a concentration of 6.0 ×10⁴ cells/cm₂ onto 24-well plates. After specific treatment for 24 h, a ﬁnal concentration of 0.5 mg/mL MTT reagent was added directly toeach well. After 2 h, the medium was removed, the formazan crystals in ECV304 cells were dissolved in dimethylsulfoxide, and the absorbance of the formazan solutionwas measured by an ELISA reader at 540 nm.
動物実験	動物モデル	Male BALB/c mice
	投薬量	150 mg/kg
	投与方法	i.p.

参考

[1] Kong CS, et al. Phytother Res. 2013, 27(3):317-23.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Combination of HDE and BIIB021 efficiently inhibits cell proliferation and induces apoptosis via downregulating hTERT in myelodysplastic syndromes [ Exp Ther Med, 2021, 21(5):503]	PubMed: 33791012
Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. [ J Nutr Biochem, 2015, 26(11):1379-84]	PubMed: 26303405

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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