Palbociclib (PD-0332991)

製品コードS4482 バッチS448202

化学情報

	Synonyms	PD 0332991	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂₄H₂₉N₇O₂
	分子量	447.53	CAS No.	571190-30-2
Solubility (25°C)*	体外	5% TFA	5 mg/mL (11.17 mM)
		DMSO	Insoluble
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Palbociclib (PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.This product has poor solubility, animal in vivo experiments are available, cell experiments please choose carefully!

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BT474 and MDA-MB-361 tumor cell lines
	濃度	0-15 μM
	反応時間	72 h
	実験の流れ	Cell viability is measured by Cell Titer Glo assay after 72 hours of treatment with vehicle or drugs. For all experiments with fulvestrant, cells are grown in estrogen free conditions, and estradiol is added to a final concentration of 10^-8 M prior to drug treatment.
動物実験	動物モデル	NCG mice injected with MDA-MB-361 cells
	投薬量	50mg/kg
	投与方法	o.g.

参考

https://pubmed.ncbi.nlm.nih.gov/15542782/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742793/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling [ Drug Resist Updat, 2025, 78:101161]	PubMed: 39499997
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants [ Nat Commun, 2025, 16(1):7622]	PubMed: 40817109
Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer [ Cell Rep Med, 2025, S2666-3791(25)00231-9]	PubMed: 40449480
Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies [ Cell Rep Med, 2025, 6(2):101964]	PubMed: 39933527
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage [ Genes Dev, 2025, 39(9-10):582-602]	PubMed: 40127955
Enlarged PML-nuclear bodies trigger conflicting cell cycle signal-mediated cytotoxicity in leukemia cells [ Cell Death Dis, 2025, 16(1):586]	PubMed: 40753178
Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM [ Cell Death Dis, 2025, 16(1):357]	PubMed: 40319068
SMAD2 linker phosphorylation impacts overall survival, proliferation, TGFβ1-dependent gene expression and pluripotency-related proteins in NSCLC [ Br J Cancer, 2025, 133(1):52-65]	PubMed: 40319202
DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair [ Cell Rep, 2025, 44(4):115452]	PubMed: 40117291
Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer [ NPJ Precis Oncol, 2025, 9(1):20]	PubMed: 39824957

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。