Palmitic acid

製品コードS3794 バッチS379401

印刷

化学情報

Chemical Structure Synonyms hexadecanoic acid, Cetylic acid Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H32O2
分子量 256.42 CAS No. 57-10-3
Solubility (25°C)* 体外 DMSO 51 mg/mL (198.89 mM)
 
 
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Palmitic acid (ヘキサデカン酸、セチル酸) は、動物、植物、微生物に見られる最も一般的な飽和脂肪酸であり、抗腫瘍活性を持ちます。 本製品は、培地などの水溶性溶媒にほとんど溶解しない脂肪酸です。細胞実験で使用する前に乳化させる必要があります。粉末でのご購入をお勧めします。
in vitro

Palmitic acid (PA) binds TLR4 via the adaptor protein MD2 and that the TLR4 signal induced by this compound stimulates dendritic cells activation and maturation accompanied by a robust IL-1β response. It is a TLR4/MD-2 ligand. This chemical exerts pro-inflammatory activity through TLR4.
in vivo

In a dose-dependent fashion, palmitic acid rapidly reduces mouse locomotor activity by a mechanism that did not rely on TLR4, MyD88, IL-1, IL-6 or TNFα but is dependent on fatty acid chain length. This compound induces anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism.

プロトコル(参考用のみ)

細胞アッセイ 細胞株 The insulinoma cell line INS-1
濃度 250 μmol/L
反応時間 24 or 48 h
実験の流れ

The INS-1 cells are seeded onto 96-well plates at 4,000 cells/well with 10% BSA and incubated with T0901317 (10 μmol/L), palmitic acid (250 μmol/L), a combination of T0901317 and this compound or PBS (mock control) for 24 or 48 h. After the treatment incubation, 20 μl of MTT solution (5 mg/mL MTT in PBS, pH 7.4) are added to each well, followed by incubation at 37°C for 4 h. The supernatants are removed from the wells and DMSO (15 μl/well) is added to dissolve the crystals. The optical density at a wavelength of 490 nm is measured using a microplate reader.
動物実験 動物モデル C57BL/6J mice
投薬量 0.3, 3, and 30 μmol/mouse
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/28463985/
  • https://pubmed.ncbi.nlm.nih.gov/25016520/
  • https://pubmed.ncbi.nlm.nih.gov/21753123/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Stromal Cell Derived Factor-1 Promotes Hepatic Insulin Resistance via Inhibiting Hepatocyte Lipophagy [ J Cell Mol Med, 2025, 29(2):e70352] PubMed: 39855896
Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways [ Sci Rep, 2025, 15(1):28774] PubMed: 40770408
Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation [ Anim Biotechnol, 2025, 36(1):2442351] PubMed: 39718035
Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring [ Research Square, 2024, 10.21203/rs.3.rs-3480364/v1] PubMed: none
Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation [ Nat Commun, 2023, 14(1):660] PubMed: 36750575
Palmitic acid induces nDNA release to cytosol and promotes microglial M1 polarization via cGAS-STING signaling pathway [ Biochim Biophys Acta Mol Cell Res, 2023, 1870(1):119385] PubMed: 36302463
FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism [ Front Pharmacol, 2022, 13:850128] PubMed: 35517790
GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling [ Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(6):158920] PubMed: 33684566
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy [ J Pineal Res, 2018, 64(1)] PubMed: 28981157

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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