受注:045-509-1970 |
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Synonyms | hexadecanoic acid, Cetylic acid | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H32O2 |
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分子量 | 256.42 | CAS No. | 57-10-3 | |
Solubility (25°C)* | 体外 | DMSO | 51 mg/mL (198.89 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. |
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in vitro | Palmitic acid (PA) binds TLR4 via the adaptor protein MD2 and that the TLR4 signal induced by PA stimulates dendritic cells activation and maturation accompanied by a robust IL-1β response. Palmitic acid is a TLR4/MD-2 ligand. It exerts pro-inflammatory activity through TLR4[1]. |
in vivo | In a dose-dependent fashion, palmitic acid rapidly reduces mouse locomotor activity by a mechanism that did not rely on TLR4, MyD88, IL-1, IL-6 or TNFα but is dependent on fatty acid chain length. Palmitic acid induces anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism[2]. |
細胞アッセイ | 細胞株 | The insulinoma cell line INS-1 |
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濃度 | 250 μmol/L | |
反応時間 | 24 or 48 h | |
実験の流れ | The INS-1 cells are seeded onto 96-well plates at 4,000 cells/well with 10% BSA and incubated with T0901317 (10 μmol/L), palmitic acid (250 μmol/L), a combination of T0901317 and palmitic acid or PBS (mock control) for 24 or 48 h. After the treatment incubation, 20 μl of MTT solution (5 mg/mL MTT in PBS, pH 7.4) are added to each well, followed by incubation at 37°C for 4 h. The supernatants are removed from the wells and DMSO (15 μl/well) is added to dissolve the crystals. The optical density at a wavelength of 490 nm is measured using a microplate reader. | |
動物実験 | 動物モデル | C57BL/6J mice |
投薬量 | 0.3, 3, and 30 μmol/mouse | |
投与方法 | i.p. |
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Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring [ Research Square, 2024, 10.21203/rs.3.rs-3480364/v1] | PubMed: none |
Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation [ Nat Commun, 2023, 14(1):660] | PubMed: 36750575 |
Palmitic acid induces nDNA release to cytosol and promotes microglial M1 polarization via cGAS-STING signaling pathway [ Biochim Biophys Acta Mol Cell Res, 2023, 1870(1):119385] | PubMed: 36302463 |
FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism [ Front Pharmacol, 2022, 13:850128] | PubMed: 35517790 |
GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling [ Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(6):158920] | PubMed: 33684566 |
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy [ J Pineal Res, 2018, 64(1)] | PubMed: 28981157 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。