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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C30H52O4 |
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分子量 | 476.73 | CAS No. | 32791-84-7 | |
Solubility (25°C)* | 体外 | DMSO | 95 mg/mL (199.27 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. |
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in vitro | Panaxatriol exerts dose-dependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol is 30 μM. Panaxatriol is found to exert its anticancer activity through induction of apoptosis. The apoptosis of DU-15 cancer cells is prompted by ROS-mediated alterations in mitochondrial membrane potential. Additionally, panaxatriol induces sub-G1 cell cycle arrest and suppresses the DU-15 cell migration ability in a concentration-dependent manner[1]. |
in vivo | Panaxatriol can relieve myelosuppression induced by radiation injury[2]. |
細胞アッセイ | 細胞株 | DU-15 cancer cells |
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濃度 | 0-120 μM | |
反応時間 | 48-72 h | |
実験の流れ | The cytotoxic effect of panaxatriol against prostate cancer cells is determined by MTT assay. DU-15 cells are cultured at the density of 1×106 cells per well in 96 well plates for 12 hrs and then treated with varying concentrations of panaxatriol (0-120 μM) for 48-72 hrs. MTT solution (20 μl) is added to each well. After-wards, 500 μl of DMSO is added to solubilize MTT formazan crystals, and ELISA plate reader is used for the determination of optical density. |
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動物実験 | 動物モデル | albino mice |
投薬量 | 200 mg/kg | |
投与方法 | oral administration |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。