PD-1/PD-L1 Inhibitor 3

製品コードS8158 バッチS815801

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C89H126N24O18S
分子量 1852.17 CAS No. 1629654-95-0
Solubility (25°C)* 体外 DMSO 100 mg/mL (53.99 mM)
Water 100 mg/mL (53.99 mM)
Ethanol 100 mg/mL (53.99 mM)
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
in vitro

PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity[1].

プロトコル(参考用のみ)

参考

  • https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014151634&tab=PCTBIBLIO

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Microphysiologically Engineered Vessel-Tumor Model to Investigate Vascular Transport Dynamics of Immune Cells [ ACS Appl Mater Interfaces, 2024, 16(18):22839-49] PubMed: 38652824
Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1 [ J Med Chem, 2024, 67(5):4036-4062] PubMed: 38442487
Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment [ Front Oncol, 2024, 14:1536406] PubMed: 39927118
On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach [ Pharmaceuticals (Basel), 2023, 16(7)1051] PubMed: 37513962
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940] PubMed: 35120895
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940] PubMed: 35120895
FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer [ ChemMedChem, 2022, e202200091] PubMed: 35388635
A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules [ Nat Chem, 2021, 10.1038/s41557-021-00829-5] PubMed: 34873299
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β [ Exp Mol Med, 2021, 53(9):1366-1378] PubMed: 34548615
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors [ ChemMedChem, 2021, 16(3):568-577] PubMed: 33085193

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。