受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C89H126N24O18S |
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分子量 | 1852.17 | CAS No. | 1629654-95-0 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (53.99 mM) | |
Water | 100 mg/mL (53.99 mM) | |||
Ethanol | 100 mg/mL (53.99 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | PD-1/PD-L1 Inhibitor 3(Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3)is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM |
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in vitro | PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity[1]. |
Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1 [ J Med Chem, 2024, 67(5):4036-4062] | PubMed: 38442487 |
On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach [ Pharmaceuticals (Basel), 2023, 16(7)1051] | PubMed: 37513962 |
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940] | PubMed: 35120895 |
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940] | PubMed: 35120895 |
FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer [ ChemMedChem, 2022, e202200091] | PubMed: 35388635 |
A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules [ Nat Chem, 2021, 10.1038/s41557-021-00829-5] | PubMed: 34873299 |
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β [ Exp Mol Med, 2021, 53(9):1366-1378] | PubMed: 34548615 |
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors [ ChemMedChem, 2021, 16(3):568-577] | PubMed: 33085193 |
Blockade of Kv1.3 potassium channel inhibits CD8+ T cell-mediated neuroinflammation via PD-1/Blimp-1 signaling [ FASEB J, 2020, 10.1096/fj.202000861RR] | PubMed: 32981181 |
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA [ Biochem J, 2020, BCJ20200697] | PubMed: 33094805 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。