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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C16H14BrN3O2 |
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分子量 | 360.21 | CAS No. | 153436-54-5 | |
Solubility (25°C)* | 体外 | DMSO | 6 mg/mL (16.65 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM). |
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in vitro | PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and cbonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF can be completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor[1]. |
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Driving role of head and neck cancer cell secretome on the invasion of stromal fibroblasts: Mechanistic insights by phosphoproteomics [ Biomed Pharmacother, 2023, 158:114176] | PubMed: 36916400 |
Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer [ Cell Death Discov, 2023, 10.1038/s41420-023-01701-w] | PubMed: 37919290 |
Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming [ Sci Signal, 2022, 15(728):eabj6915] | PubMed: 35380879 |
The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways [ Sci Signal, 2022, 15(728):eabj6915] | PubMed: 35380879 |
Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [ J Biol Chem, 2022, 298(10):102419] | PubMed: 36037968 |
Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [ J Biol Chem, 2022, 298(10):102419] | PubMed: 36037968 |
Control of osteoblast regeneration by a train of Erk activity waves [ Nature, 2021, 10.1038/s41586-020-03085-8] | PubMed: 33408418 |
Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration [ Int J Mol Sci, 2021, 22(8)3945] | PubMed: 33920448 |
Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells [ FEBS Lett, 2021, 595(5):563-576] | PubMed: 33421110 |
Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells [ FEBS Lett, 2021, 10.1002/1873-3468.14032] | PubMed: 33421110 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。