Penciclovir

製品コードS4184 バッチS418401

化学情報

	Synonyms	BRL-39123, VSA 671,NSC-759624	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₀H₁₅N₅O₃
	分子量	253.26	CAS No.	39809-25-1
Solubility (25°C)*	体外	DMSO	34 mg/mL (134.24 mM)
		Water	1 mg/mL (3.94 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.
in vitro	Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase. ^[1] Penciclovir has activity against several herpes viruses with IC50 of 37.9 μM for HHV-6A and 77.8 μM for HHV-6B. ^[2] Herpes simplex virus-1 studies indicate that Penciclovir induces apoptosis without causing much genotoxicity. ^[3]

製品説明

Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.

in vitro

Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase. ^[1] Penciclovir has activity against several herpes viruses with IC50 of 37.9 μM for HHV-6A and 77.8 μM for HHV-6B. ^[2] Herpes simplex virus-1 studies indicate that Penciclovir induces apoptosis without causing much genotoxicity. ^[3]

プロトコル(参考用のみ)

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Safety, efficacy and delivery of multiple nucleoside analogs via drug encapsulated carbon (DECON) based sustained drug release platform [ Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9]	PubMed: 35314347
A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase [ Antiviral Res, 2021, S0166-3542(21)00068-1]	PubMed: 33894278
Quinoline and Quinazoline Derivatives Inhibit Viral RNA Synthesis by SARS-CoV-2 RdRp [ ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083]	PubMed: 34038639
Tenofovir Prodrugs Potently Inhibit Epstein-Barr Virus Lytic DNA Replication by Targeting the Viral DNA Polymerase [ Proc Natl Acad Sci U S A, 2020, 14;202002392]	PubMed: 32409608
Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing [ Sci Adv, 2020, 6(49)eabd9443]	PubMed: 33277262
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734]	PubMed: 32511305

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。