Pentoxifylline

製品コードS4345 バッチS434502

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₃H₁₈N₄O₃

分子量

278.31

CAS No.

6493-05-6

Solubility (25°C)*

体外

DMSO

55 mg/mL (197.62 mM)

Water

55 mg/mL (197.62 mM)

Ethanol

55 mg/mL (197.62 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.75mg/ml (9.88mM)	Taking the 1 mL working solution as an example, add 50 μL of 55 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.39mg/ml (1.40mM)	Taking the 1 mL working solution as an example, add 50 μL of 7.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Pentoxifyllineは、細胞内cAMPを上昇させ、PKAを活性化し、TNFおよびロイコトリエン合成を阻害し、炎症と自然免疫を軽減する競合的非選択的ホスホジエステラーゼ阻害剤です。
in vitro	Pentoxifylline exhibits synergism with CDDP in killing MCF-7/E6 cells but does not affect sensitivity of the control cells. This compound inhibits G2 checkpoint function to a greater extent in MCF-7/E6 than in the parental cells. It acts primarily by increasing red blood cell deformability, by reducing blood viscosity and by decreasing the potential for platelet aggregation and thrombus formation. This chemical is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity. It (10 μM) suppresses the production of both biologically active TNF and TNF mRNA expression by more than 50% in LM cells. This agent blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation in RAW 264.7 macrophages. When combined with Dexamethasone, it causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone in RAW 264.7 macrophages.
in vivo	Pentoxifylline (500 mg) markedly inhibits increases in the serum levels of TNF and IL-6, as well as the effects on coagulation and fibrinolysis, in chimpanzees. This compound along with Endotoxin (4 ng/kg) also has a significant effect on thrombin generation in chimpanzees.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/7712469/
https://pubmed.ncbi.nlm.nih.gov/3308412/
https://pubmed.ncbi.nlm.nih.gov/2460096/

https://pubmed.ncbi.nlm.nih.gov/2358784/
https://pubmed.ncbi.nlm.nih.gov/8282778/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable [ Antiviral Res, 2023, 216:105674]	PubMed: 37459896
Repurposing FDA-approved drugs for anti-aging therapies. [ Biogerontology, 2016, 17(5-6):907-920]	PubMed: 27484416
Repurposing FDA-approved drugs for anti-aging therapies: screening of a compound library in the rotifer Brachionus manjavacas [ Biogerontology, 2016, 907-920]	PubMed: nan

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。