Pepstatin A

製品コードS7381 バッチS738113

印刷

化学情報

Chemical Structure Synonyms Pepstatin Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C34H63N5O9
分子量 685.89 CAS No. 26305-03-3
Solubility (25°C)* 体外 DMSO 70 mg/mL (102.05 mM)
Ethanol (warmed with 50ºC water bath) 3 mg/mL (4.37 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
in vitro

Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, this compound inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. [1]

This chemical laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression. [2]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 NCM460 cells
濃度 10 μM
反応時間 24 h
実験の流れ

Cells were treated with indicated concentrations of this compound.
動物実験 動物モデル Male Wistar rats
投薬量 0.5, 1, 10 and 50 mg/kg
投与方法 p.o.

参考

  • https://pubmed.ncbi.nlm.nih.gov/3045820/
  • https://pubmed.ncbi.nlm.nih.gov/16567424/
  • https://pubmed.ncbi.nlm.nih.gov/35974017/
  • https://pubmed.ncbi.nlm.nih.gov/4912600/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentation [ Nat Commun, 2025, 16(1):4069] PubMed: 40307254
SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin [ Front Cell Neurosci, 2025, 19:1623747] PubMed: 40894005
Proteome changes associated with effect of high dose single-fractionation radiation on lung adenocarcinoma cell lines [ Sci Rep, 2025, 15(1):24245] PubMed: 40624183
Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis [ Cell Rep Med, 2024, 5(4):101503] PubMed: 38593810
Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets [ Anim Nutr, 2024, 20:16:409-421.] PubMed: 38371474
Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets [ Anim Nutr, 2024, 16:409-421] PubMed: 38371474
Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling [ Cells, 2024, 13(11)953] PubMed: 38891085
Identification of organs of origin of macrophages that produce presepsin via neutrophil extracellular trap phagocytosis [ Sci Rep, 2024, 14(1):16386] PubMed: 39013974
Lotus Sprout Extract Induces Selective Melanosomal Autophagy and Reduces Pigmentation [ J Cosmet Dermatol, 2024, 10.1111/jocd.16587] PubMed: 39305105
Maintenance of neuronal TDP-43 expression requires axonal lysosome transport [ bioRxiv, 2024, 2024.09.30.615241] PubMed: 39803527

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。