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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C22H21F3N6O3S |
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分子量 | 506.5 | CAS No. | 717906-29-1 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (197.43 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively. |
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in vitro | In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. [2] PF-431396 consistently inhibits the increase in protein tyrosine phosphorylation (PY) induced by the absence of added calcium and induced by W-7 in the presence of calcium. [3] |
キナーゼアッセイ | Kinase assays and selectivity profiling | |
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Kinase assays for PYK2 and FAK are determined as followed: unactivated full-length, C-terminal his-tagged human proteins are used in place of the Src-activated kinase domain protein and that test compounds are preincubated with enzyme for 1 h prior to the addition of 500 μM ATP. IC50 determinations are generated from 8 point dose response curves. Selectivity profiling against a diverse panel of kinases is performed by a commercial vendor and reported as average percent inhibition of duplicate tests. |
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Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia [ Nat Commun, 2023, 14(1):6270] | PubMed: 37805579 |
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells [ Cell Rep, 2023, 42(5):112529] | PubMed: 37200193 |
Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects [ J Exp Clin Cancer Res, 2021, 40(1):364] | PubMed: 34784956 |
SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase [ Cancers (Basel), 2021, 13(24)6344] | PubMed: 34944965 |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction [ Nat Commun, 2020, 11(1):3282] | PubMed: 32612176 |
Myeloid cells provide critical support for T-ALL in vivo [ The University of Texas at Austin, 2020, ] | PubMed: None |
Inositol polyphosphate multikinase is a metformin target that regulates cell migration [ FASEB J, 2019, 33(12):14137-14146] | PubMed: 31657647 |
Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. [ Cancer Biol Ther, 2018, 19(4):316-327] | PubMed: 29303405 |
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. [ Mol Cell, 2017, 67(3):512-527] | PubMed: 28757207 |
Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders. [ J Immunol, 2017, 198(5):2082-2092] | PubMed: 28087670 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。