PFK158

製品コードS8807 バッチS880702

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₈H₁₁F₃N₂O

分子量

328.29

CAS No.

1462249-75-7

Solubility (25°C)*

体外

DMSO

66 mg/mL (201.04 mM)

Ethanol

4 mg/mL (12.18 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	3.3mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 66 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	3.3mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 66 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
in vitro	PFK158 results in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. PFK158 treatment sensitizes chemoresistant cells and induces cell death^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	Female athymic nude mice (nu/nu) (5-6 weeks old)
	投薬量	25 mg/kg
	投与方法	i.p.

参考

[1] Mondal S, et al. Int J Cancer. 2019, 144(1):178-189.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance [ Nat Metab, 2022, 4(10):1287-1305]	PubMed: 36203054
Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells [ Cancers (Basel), 2022, 14(9)2113]	PubMed: 35565242
In Vivo Targeting Replication Protein A for Cancer Therapy [ Front Oncol, 2022, 12:826655]	PubMed: 35251993
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes [ Front Immunol, 2021, 12:669456]	PubMed: 34163475
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes [ Front Immunol, 2021, 12:669456]	PubMed: 34163475
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer [ Cancer Metab, 2021, 9(1):33]	PubMed: 34556188
Deamidation Shunts RelA From Mediating Inflammation to Aerobic Glycolysis [ Cell Metab, 2020, 5;31(5):937-955e7]	PubMed: 32325032

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。