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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C18H11F3N2O |
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分子量 | 328.29 | CAS No. | 1462249-75-7 | |
Solubility (25°C)* | 体外 | DMSO | 15 mg/mL (45.69 mM) | |
Ethanol | 4 mg/mL (12.18 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors. |
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in vitro | PFK158 results in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. PFK158 treatment sensitizes chemoresistant cells and induces cell death[1]. |
動物実験 | 動物モデル | Female athymic nude mice (nu/nu) (5-6 weeks old) |
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投薬量 | 25 mg/kg | |
投与方法 | i.p. |
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance [ Nat Metab, 2022, 4(10):1287-1305] | PubMed: 36203054 |
Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells [ Cancers (Basel), 2022, 14(9)2113] | PubMed: 35565242 |
In Vivo Targeting Replication Protein A for Cancer Therapy [ Front Oncol, 2022, 12:826655] | PubMed: 35251993 |
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes [ Front Immunol, 2021, 12:669456] | PubMed: 34163475 |
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes [ Front Immunol, 2021, 12:669456] | PubMed: 34163475 |
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer [ Cancer Metab, 2021, 9(1):33] | PubMed: 34556188 |
Deamidation Shunts RelA From Mediating Inflammation to Aerobic Glycolysis [ Cell Metab, 2020, 5;31(5):937-955e7] | PubMed: 32325032 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。