Phenibut

製品コードS4892 バッチS489201

印刷

化学情報

Chemical Structure Synonyms Aminophenylbutyric acid, Fenibut, Fenigam, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C10H13NO2
分子量 179.22 CAS No. 1078-21-3
Solubility (25°C)* 体外 DMSO 35 mg/mL (195.29 mM)
 
 
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
in vitro

Phenibut has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABAB and, to some extent, at GABAA receptors. This compound also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[1].
in vivo

At doses that do not affect motor activity (e.g., 20 mg/kg i.p.), Phenibut inhibits food conditioned reflexes in mice. At doses higher than 70 mg/kg i.p., this compound reduces motor and exploratory activities, rearings, muscle tone, coordination and body temperature. Following intravenous administration to either rabbits or rats it is not metabolized. This chemical is largely excreted in the urine. At 15, 30, 60, or 90 min following i.v. administration it is found in liver, kidneys, and urine. Traces of the compound are found in blood and brain. 180 min after i.v. injection only traces of the drug are found in all tissues studied. In cats and dogs, it, after a single dose of 50 mg/kg i.v., is excreted in the urine unchanged. The acute toxicity of this substance is low. Its LD50 is 900 mg/kg i.p. in mice and 700 mg/kg i.p. in rats[1]. Administration of this agent leads to decreases in horizontal movement activity and some elements of investigative behavior in rabbits in the open field, along with decreases in the reactivity of the animals to emotionally significant stimuli[2].

プロトコル(参考用のみ)

動物実験 動物モデル Chinchilla rabbits
投薬量 40 mg/kg
投与方法 s.c.

参考

  • https://pubmed.ncbi.nlm.nih.gov/11830761/
  • https://pubmed.ncbi.nlm.nih.gov/18607733/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。