Phytol

製品コードS5121 バッチS512101

印刷

化学情報

Chemical Structure Synonyms Trans-Phytol Storage
(From the date of receipt)		 2 years -80°C liquid
化学式

C20H40O
分子量 296.53 CAS No. 150-86-7
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
in vitro Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα)[1]. The addition of phytol upregulates the expression of PPARα-target genes at both mRNA and protein levels in PPARα-expressing HepG2 hepatocytes. Phytol is a specific ligand for PPARα, although it can activate PPARγ moderately[3]. In vitro, phytol reduces the motor activity of worms and causes their death. Additionally, phytol at sublethal doses (25 µg/mL) reduces the number of Schistosoma mansoni eggs[4].
in vivo In many animal studies, phytol is used as a precursor of phytanic acid. Addition of phytol to the diet results in an increase of phytol metabolites in tissues and plasma[1]. In vivo, a single dose of phytol (40 mg/kg) administered orally to mice infected with adult S. mansoni results in total and female worm burden reductions of 51.2% and 70.3%, respectively. Moreover, phytol reduces the number of eggs in faeces (76.6%) and the frequency of immature eggs (oogram pattern) is significantly reduced. In medicinal fields, phytol has shown antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. Phytol is an excellent immunostimulant, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity[4].
密度 0.8 g/mL

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Molt 4B cells
濃度 10, 20, 40, 80, 100 μM
反応時間 3 days
実験の流れ

Exponentially growing cells are placed at 3 to 4×l05 cells/ml in the culture flask and cultivated in the presence of vehicle or phytol. After cultivation for 3 days, the cell number is counted by a hemocytometer.
動物実験 動物モデル Balb/c mice infected with S. mansoni
投薬量 40 mg/kg
投与方法 oral

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。