Piribedil

製品コードS3656 バッチS365601

化学情報

	Synonyms	Trivastal, Trivastan	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₆H₁₈N₄O₂
	分子量	298.34	CAS No.	3605-01-4
Solubility (25°C)*	体外	DMSO	59 mg/mL (197.76 mM)
		Ethanol	59 mg/mL (197.76 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
in vitro	Piribedil is a direct dopamine receptor agonist used for the treatment of Parkinson's disease and of other clinical disorders involving dysfunction of the dopaminergic system. Piribedil has 20 times higher affinity for dopamine D3 than for dopamine D2-like receptors, and very low affinity for the dopamine D1 receptor subtype in rat brain. Piribedil is a potent inhibitor at dopamine D3 receptors with affinity between 30 and 60 nM^[1]. Although piribedil is not a potent agent, its affinity at hα2A- and hα2C-ARs was comparable to that at D2 receptors^[3].
in vivo	Piribedil (2.5-4.0 mg/kg s.c.) accelerates hippocampal NE synthesis, elevates dialysis levels of NE in hippocampus and frontal cortex, and blocks hypnotic-sedative properties of the α2-AR agonist xylazine^[3]. Although a subchronic treatment with piribedil (0.1-2 mg/kg) is not effective, a dose of 0.3 mg/kg administered for 3 weeks significantly reverses the akinetic deficits produced by the striatal dopamine depletion and progressively improves attentional deficits. When coadministered with the dopamine prodrug L-DOPA (3 mg/kg), piribedil (0.3 mg/kg) promotes a rapid and full recovery of preoperative performance^[2].

プロトコル(参考用のみ)

動物実験	動物モデル	Wistar rats
	投薬量	2.5-4.0 mg/kg
	投与方法	s.c.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality [ Cell Rep Methods, 2023, 3(1):100381]	PubMed: 36814839

Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality [ Cell Rep Methods, 2023, 3(1):100381]

PubMed: 36814839

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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