受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||
化学式 | C39H62O13 |
||||||
分子量 | 738.90 | CAS No. | 55916-51-3 | ||||
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (135.33 mM) | ||||
体内 (毎回新しく調製した物を用意してください) |
|
||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities. |
---|---|
in vitro | Polyphyllin VI (PPVI) induces activation of the NLRP3 inflammasome and exerts anti-proliferative effect via the induction of the ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer (NSCLC).<sup><a class="sref"href="#s_ref">[1]</a></sup> |
in vivo | Polyphyllin VI (PPVI), a main saponin isolated from TTM, activates the NLRP3 inflammasome in A549-bearing athymic nude mice.<sup><a class="sref"href="#s_ref">[1]</a></sup> |
細胞アッセイ | 細胞株 | A549, H1299 cells |
---|---|---|
濃度 | 3-6 μM | |
反応時間 | 24 h, 48 h, 72 h | |
実験の流れ | A549 or H1299 cells seeded onto 96-well cell plates at a density of 5×103 cells/well are treated with PPVI under the indicated concentrations for 24, 48, and 72 h. After treatment, 10 μL of MTT solution (5 mg/mL) is added to each well and continued to incubate for another 4 h. The medium is then removed and 150 L of DMSO is added to each well to dissolve the formed formazan in the cells. After shaking at low speed for 10 min at room temperature, the colorimetric reading of the solute mixture is then determined by spectrophotometer at OD 570 nm. |
|
動物実験 | 動物モデル | A549-Bearing Athymic Nude Mice |
投薬量 | 2.5, 5, and 10 mg/kg | |
投与方法 | i.p. |
SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization [ Redox Biol, 2024, 70:103039] | PubMed: 38241838 |
Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement [ Int J Oral Sci, 2024, 16(1):3] | PubMed: 38221531 |
The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy [ bioRxiv, 2024, 2024.03.19.585812] | PubMed: 38562843 |
High‑throughput screening identification of a small‑molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis [ Int J Oncol, 2023, 62(3)42] | PubMed: 36825585 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。