Pranoprofen

製品コードS1960 バッチS196002

印刷

化学情報

Synonyms

Pyranoprofen,Pranopulin

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₃NO₃

分子量

255.27

CAS No.

52549-17-4

Solubility (25°C)*

体外

DMSO

51 mg/mL (199.78 mM)

Ethanol

51 mg/mL (199.78 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Pranoprofen (Pyranoprofen,Pranopulin)は、眼科における抗炎症薬として使用される非ステロイド性COX阻害剤である。
in vitro	Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. This compound inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. It alone induces eIF2alpha phosphorylation, which is further increased by ER stress. This chemical inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells. It (0.0625 to 1.0 g/L) has poignant cytotoxicity to human corneal endothelial (HCE) cells, and the extent of its cytotoxicity is dose- and time-dependent. This compound induces plasma membrane permeability elevation, DNA fragmentation, and apoptotic body formation, proving its apoptosis inducing effect on HCE cells. It above 0.0625 g/L has poignant cytotoxicity on HCE cells in vitro by inducing cell apoptosis, and should be carefully employed in eye clinic.
in vivo	Pranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively. This compound is excreted in the urine exclusively in the form of pranoprofen glucuronide in rabbit. It, especially the R(-)-isomer, is significantly distributed in the kidney of rabbit. This chemical has a preference for glucosidation rather than glucuronidation in mice at low doses in spite of having a higher capacity of glucuronidation.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/19114067/
https://pubmed.ncbi.nlm.nih.gov/24641202/
https://pubmed.ncbi.nlm.nih.gov/2098547/

https://pubmed.ncbi.nlm.nih.gov/8364476/
https://pubmed.ncbi.nlm.nih.gov/2098544/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

PGE2 pathway mediates oxidative stress-induced ferroptosis in renal tubular epithelial cells [ FEBS J, 2022, 10.1111/febs.16609]	PubMed: 36031392
Role of Interleukin-33 in Staphylococcus epidermidis-Induced Septicemia [ Front Immunol, 2020, 11:534099]	PubMed: 33178181
Expression of programmed cell death1 in T follicular helper cells is regulated by prostaglandin E2 secreted by HBV-infected HepG2. 2.1. 5 cells [Sui Z Mol Med Rep, 2017, 15(6):4305-4311]	PubMed: 28440484

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。