PRI-724 (Foscenvivint)

製品コードS8968 バッチS896801

化学情報

	Synonyms	C-82 prodrug, ICG-001 analog	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₃₃H₃₅N₆O₇P
	分子量	658.64	CAS No.	1422253-38-0
Solubility (25°C)*	体外	DMSO	100 mg/mL (151.82 mM)
		Ethanol	2 mg/mL (3.03 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Foscenvivint (PRI-724) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.
in vivo	Foscenvivint (PRI-724) reduces liver fibrosis and hepatic hydroxyproline levels in HCV mice while attenuating αSMA induction. It leads to increased levels of matrix metalloproteinase (MMP)-8 mRNA in the liver, along with elevated levels of intrahepatic neutrophils and macrophages/monocytes. In conclusion, this compound ameliorates HCV-induced liver fibrosis in mice and is a drug candidate which possesses antifibrotic effect.

製品説明

Foscenvivint (PRI-724) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.

in vivo

Foscenvivint (PRI-724) reduces liver fibrosis and hepatic hydroxyproline levels in HCV mice while attenuating αSMA induction. It leads to increased levels of matrix metalloproteinase (MMP)-8 mRNA in the liver, along with elevated levels of intrahepatic neutrophils and macrophages/monocytes. In conclusion, this compound ameliorates HCV-induced liver fibrosis in mice and is a drug candidate which possesses antifibrotic effect.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	SCC-25 cells
	濃度	0.85 µM
	反応時間	48 h
	実験の流れ	Cells were treated with various concentrations of Foscenvivint (PRI-724).
動物実験	動物モデル	HCV GT1b transgenic mice (MxCre^+/−/CN2-29^+/−)
	投薬量	5 mg/kg, 15 mg/kg, 20 mg/kg; 1 mg/kg
	投与方法	IP/SC

参考

https://pubmed.ncbi.nlm.nih.gov/28336942/
https://pubmed.ncbi.nlm.nih.gov/35163171/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Off-pore nucleoporin sPOM121 transcriptionally propels β-Catenin driven tumor progression and immune escape in prostate cancer [ Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629]	PubMed: 40709833
Inhibition of Wnt/β-catenin increases anti-tumor activity by synergizing with sorafenib in hepatocellular carcinoma [ Cell Death Dis, 2025, 16(1):466]	PubMed: 40593458
Modulating Wnt/β-catenin pathway activity to enhance chemosensitivity in cholangiocarcinoma [ Biomed Pharmacother, 2025, 188:118225]	PubMed: 40472719
MEN1 Deficiency-Driven Activation of the β-Catenin-MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance [ Adv Sci (Weinh), 2024, 11(35):e2308417]	PubMed: 39041891
Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms [ Cell Rep, 2024, 43(7):114414]	PubMed: 38943643
Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis [ Nat Commun, 2023, 14(1):4671]	PubMed: 37537199
Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia [ Cell Rep, 2023, 42(7):112804]	PubMed: 37453060
β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer [ J Transl Med, 2023, 21(1):50]	PubMed: 36703130
Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells [ Int J Mol Sci, 2023, 24(13)10448]	PubMed: 37445628
Critical role for ribonucleoside-diphosphate reductase subunit M2 in ALV-J-induced activation of Wnt/β-catenin signaling via interaction with P27 [ J Virol, 2023, 97(8):e0026723]	PubMed: 37582207

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。