Propranolol HCl

製品コードS4076 バッチS407602

印刷

化学情報

Chemical Structure Synonyms AY-64043, ICI-45520, NCS-91523 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H21NO2.HCl
分子量 295.8 CAS No. 318-98-9
Solubility (25°C)* 体外 DMSO 59 mg/mL (199.45 mM)
Water 59 mg/mL (199.45 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.
in vitro

Propranolol, a non-selective β1 and β2 adrenergic blocker, has no effect on the proliferation of neonatal mouse cardiac fibroblasts (NMCFs).[2]
in vivo

Propranolol, an anti-arrhythmic drugs, consistently reduces the heart rates of adult mice by approximately 10%-20%, whereas isoproterenol has the opposite effect.[2]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 neonatal mice cardiomyocytes (NMCMs)
濃度 10, 20, 40, 50, and 100 μM
反応時間 6, 12, 18, and 24 h
実験の流れ

In vitro, the neonatal mice cardiomyocytes (NMCMs) are treated with different drugs of different concentration, including isoproterenol (0, 1, 2.5, 5, 10, 20, and 50 μM); amiodarone (0, 1, 2.5, 5, 10, 20, and 50 μM); metoprolol (0, 10, 20, 30, 50, 100, 150, and 200 μM); propranolol (0, 10, 20, 40, 50, and 100 μM); lidocaine (0, 1, 2.5, 5, 10, 20, and 50 μM); verapamil(0, 1, 2.5, 5, 10, 20, and 50 μM);ivabradine (0, 1, 2, 3, 5, 10, and 20 μM). And the concentrations of drugs that promote CMs proliferation most significantly are chosen for subsequent experiments, including isoproterenol (10 μM), amiodarone (5 μM), metoprolol (20 μM), propranolol (20 μM), lidocaine (5 μM), verapamil (2.5 μM), ivabradine (3 μM) for NMCMs, NMCFs, and hPSC-CM.
動物実験 動物モデル 1-day-old neonatal mice; 12-week-old adult mice
投薬量 10 mg/kg/d
投与方法 s.c.; ALZET Osmotic Pumps

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Multiple cancer cell types release LIF and Gal3 to hijack neural signals [ Cell Res, 2024, 10.1038/s41422-024-00946-z] PubMed: 38467743
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Ketone bodies promote stroke recovery via GAT-1-dependent cortical network remodeling [ Cell Reports, 2023, 42(4)] PubMed: None
Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma [ EBioMedicine, 2022, 82:104149] PubMed: 35816899
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468] PubMed: 35263588
KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation [ Stem Cell Res Ther, 2022, 13(1):287] PubMed: 35765105
Targeting the β2 -adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism [ J Pathol, 2022, 10.1002/path.6020] PubMed: 36245401
Targeting ADRB2 enhances sensitivity of non-small cell lung cancer to VEGFR2 tyrosine kinase inhibitors [ Cell Death Discov, 2022, 8(1):36] PubMed: 35075132
LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy [ Front Endocrinol (Lausanne), 2022, 13:895360] PubMed: 35813614
LPIN1 Induces Gefitinib Resistance in EGFR Inhibitor-Resistant Non-Small Cell Lung Cancer Cells [ Cancers (Basel), 2022, 14(9)2222] PubMed: 35565351

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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