Puromycin Dihydrochloride

製品コードS7417 バッチS741712

印刷

化学情報

Synonyms

CL13900 2HCl

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₂H₂₉N₇O₅.2HCl

分子量

544.43

CAS No.

58-58-2

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

100 mg/mL (183.67 mM)

Water (warmed with 50ºC water bath)

100 mg/mL (183.67 mM)

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation.
in vitro	The antibiotic puromycin is produced by the actinoniycete, Streptornyces alboniger, and has been used as a tool for studying protein synthesis in a number of systems. ^[1] Puromycin can be used for the selection of recombinant cells from noncultured cells. ^[2]
in vivo	Puromycin (aminonucleoside) inhibits protein synthesis leading to proteinuria & glomerulosclerosis/nephrosis.^[4]

製品説明

Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation.

in vitro

The antibiotic puromycin is produced by the actinoniycete, Streptornyces alboniger, and has been used as a tool for studying protein synthesis in a number of systems. ^[1]

Puromycin can be used for the selection of recombinant cells from noncultured cells. ^[2]

in vivo

Puromycin (aminonucleoside) inhibits protein synthesis leading to proteinuria & glomerulosclerosis/nephrosis.^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	1.6 μM
	反応時間	72 h
	実験の流れ	Cells were treated with different concentrations of drug for 72 h.
動物実験	動物モデル	Male Sprague-Dawley rats
	投薬量	5 mg/100 g
	投与方法	i.v.

参考

https://pubmed.ncbi.nlm.nih.gov/14211122/
https://pubmed.ncbi.nlm.nih.gov/15385422/
https://pubmed.ncbi.nlm.nih.gov/28971619/

https://pubmed.ncbi.nlm.nih.gov/3953770/
https://pubmed.ncbi.nlm.nih.gov/32435426/
https://pubmed.ncbi.nlm.nih.gov/11397778/

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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