PDTC (Pyrrolidinedithiocarbamate ammonium)

製品コードS3633 バッチS363305

印刷

化学情報

Synonyms

APDC, Pyrrolidine dithiocarbamic acid ammonium salt

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₅H₉NS₂.H₃N

分子量

164.29

CAS No.

5108-96-3

Solubility (25°C)*

体外

DMSO

33 mg/mL (200.86 mM)

Water

33 mg/mL (200.86 mM)

Ethanol

11 mg/mL (66.95 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
in vitro	Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague-Dawley rats
	投薬量	50, 100, and 200 mg/kg
	投与方法	i.v.

参考

https://pubmed.ncbi.nlm.nih.gov/24963944/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway [ Gut Microbes, 2024, 16(1):2351532]	PubMed: 38727248
Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway [ Gut Microbes, 2024, 16(1):2351532]	PubMed: 38727248
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The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via NF-κB/MMP9 [ CNS Neurosci Ther, 2024, 30(12):e70130]	PubMed: 39648661
Helicobacter pylori with trx1 high expression promotes gastric diseases via upregulating the IL23A/NF-κB/IL8 pathway [ Helicobacter, 2024, 29(2):e13072]	PubMed: 38686467
Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity [ J Cancer Res Clin Oncol, 2024, 150(3):159]	PubMed: 38530432
A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [ Sci Adv, 2024, 10(34):eadl3975]	PubMed: 39167656

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。