Pyrvinium pamoate

製品コードS5816 バッチS581603

印刷

化学情報

Synonyms

Pyrvinium embonate

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₇₅H₇₀N₆O₆

分子量

1151.39

CAS No.

3546-41-6

Solubility (25°C)*

体外

DMSO

25 mg/mL (21.71 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.400mg/ml (0.35mM)	Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.100mg/ml (0.09mM)	Taking the 1 mL working solution as an example, add 50 μL of 2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Pyrvinium pamoate(Pyrvinium embonate)は、蟯虫に有効な駆虫薬です。

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

High-throughput drug screening in advanced pre-clinical 3D melanoma models identifies potential first-line therapies for NRAS-mutated melanoma [ Journal of Experimental & Clinical Cancer Research, October 1, 2025, 278]	PubMed: nan
Synergy between Pyrvinium Pamoate and Azoles against Exophiala dermatitidis [ Antimicrobial Agents and Chemotherapy, March 27, 2018, e02361-17]	PubMed: 29437619
Pyrvinium Pamoate Induces Cell Apoptosis and Autophagy in Colorectal Cancer [ Anticancer Research, March 2024, 44(3):1193-1199]	PubMed: 38423653
Pyrvinium Pamoate Induces Cell Apoptosis and Autophagy in Colorectal Cancer [ Anticancer Research, March 15, 2024, 1193-1199]	PubMed: nan
Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma [ Biomedicine & Pharmacotherapy, August 2024, 177:116991]	PubMed: 38906021
Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species [ Infect Drug Resist, 2025, 18:783-789]	PubMed: 39958982
Wnt/β-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma [ Endocrine, 2024, 10.1007/s12020-024-03887-0]	PubMed: 38806891
Repurposing FDA-Approved Drugs for Temozolomide-Resistant IDH1 Mutant Glioma Using High-Throughput Miniaturized Screening on Droplet Microarray Chip [ Adv Healthc Mater, 2023, e2300591.]	PubMed: 37162029
Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo [ Front Cell Infect Microbiol, 2022, 12:1074903]	PubMed: 36569209
The FDA-Approved Drug Pyrvinium Selectively Targets ER+ Breast Cancer Cells with High INPP4B Expression [ Cancers (Basel), 2022, 15(1)135]	PubMed: 36612130

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。