Q-VD-Oph

製品コードS7311 バッチS731102

化学情報

	Synonyms	Quinoline-Val-Asp-Difluorophenoxymethylketone	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₆H₂₅F₂N₃O₆
	分子量	513.49	CAS No.	1135695-98-5
Solubility (25°C)*	体外	DMSO	100 mg/mL (194.74 mM)
		Ethanol	100 mg/mL (194.74 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Q-VD-Oph（Quinoline-Val-Asp-Difluorophenoxymethylketone）は、強力なパンカスパーゼ阻害剤であり、カスパーゼ1、3、8、9に対して25～400nMのIC50を示します。Q-VD-OPhはHIV感染を阻害することができます。
in vitro	Q-VD-OPh （5-100 μM） potently inhibits Actinomycin D-induced DNA laddering and subsequent apoptosis with minimal toxicity in WEHI 231 cells. Q-VD-OPh prevents caspase mediated cleavage of PARP and activation of the major initiator and effector caspases. Q-VD-OPh protects cardiac myocytes from virus-induced apoptosis in vitro.
in vivo	Q-VD-OPh inhibits caspase-1 activity, IL-18 protein expression, and neutrophil infiltration during ischemic ARF in mice. In vivo, caspase inhibition by Q-VD-OPh provides protection from virus-induced myocardial injury, with a significant reduction in caspase-3 activity. In TgCRND8 mice, Q-VD-OPh inhibits caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	WEHI-231 cells
	濃度	~1000 μM
	反応時間	4 hours
	実験の流れ	Caspase inhibitors are added at the indicated concentrations 30 minutes prior to the addition of apoptotic stimuli. Viability and cell number are determined by trypan blue exclusion from three random fields of greater than 200 cells/field. All experiments are performed a minimum of three times.
動物実験	動物モデル	C57BL/6 mice
	投薬量	~120 mg/kg
	投与方法	Intraperitoneal administration

参考

https://pubmed.ncbi.nlm.nih.gov/12815277/
https://pubmed.ncbi.nlm.nih.gov/12815277/
https://pubmed.ncbi.nlm.nih.gov/12393844/

https://pubmed.ncbi.nlm.nih.gov/15452224/
https://pubmed.ncbi.nlm.nih.gov/20057974/

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カスタマーフィードバック

: Data from [Data independently produced by , , Mol Nutr Food Res, 2017, 61(12)]

: Data from [Data independently produced by , , Neurochem Res, 2018, 43(6):1200-1209]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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