受注:045-509-1970 |
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Synonyms | Chinic acid, Kinic acid | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C7H12O6 |
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分子量 | 192.17 | CAS No. | 77-95-2 | |
Solubility (25°C)* | 体外 | DMSO | 38 mg/mL (197.74 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid. |
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in vitro | Quinic acid inhibits NF-nB activity in cells grown in tissue culture in vitro[1]. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2 h with Quinic acid (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. Quinic acid inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. It inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of Quinic acid to inhibit vascular inflammation such as atherosclerosis[2]. Quinic acids are capable of promoting neurite outgrowth. Treatment of PC12 cells with quinic acids instead of NGF induces neuronal differentiation[3]. |
in vivo | Quinic acid increases splenic leukocyte numbers in vivo[1]. |
細胞アッセイ | 細胞株 | Raji cell |
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濃度 | 0-2.5mg/ml | |
反応時間 | 48 h | |
実験の流れ | Raji cells (2×105) are cultured in the presence of indicated concentrations of C-Med 100, QAA or QA. Growth rate is assayed after 48 h by counting triplicate samples of duplicate cultures in a Coulter cell counter. | |
動物実験 | 動物モデル | C57BL/6 mice |
投薬量 | 1, 2 and 4 mg/ml | |
投与方法 | oral |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。