Quinidine hemisulfate hydrate

製品コードS3751 バッチS375101

印刷

化学情報

Synonyms

Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₀H₂₄N₂O₂.1/2H₂SO₄.H₂O

分子量

391.47

CAS No.

6591-63-5

Solubility (25°C)*

体外

DMSO

100 mg/mL (255.44 mM)

Ethanol

100 mg/mL (255.44 mM)

Water

9 mg/mL (22.99 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Quinidine hemisulfate hydrate(キニジン、ピタイン、β-キニーネ、(+)-キニジン)は、電位依存性ナトリウムチャネルの遮断薬として作用し、抗ムスカリン作用および抗マラリア作用も持ちます。
in vitro	Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates.
in vivo	Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HMM cell lines HIB, and TRA
	濃度	2.5, 5, 10, 25 μM
	反応時間	4 days
	実験の流れ	Cells were cultured on T25 cm² flasks in the presence of different concentrations of quinidine for 4 days. Bromodeoxyuridine was added for 8.5 hours, after which cells were trypsinized and spun down for 10 minutes at 1500 revolutions per minute. Cells were washed twice in 1% BSA/phosphate-buffered saline (PBS) and fixed with 70% ethanol on ice. DNA was denatured by 2N HCl/Triton X100 at room temperature for 30 minutes and sodium tetraborate was added to neutralize the pH level. After centrifugation, cells were resuspended in 1% BSA/0.5% Tween 20/PBS and the cell concentration was adjusted to 1 x 10⁶ cells per test.
動物実験	動物モデル	Lewis rats
	投薬量	80 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/6467192/
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1034.7020&rep=rep1&type=pdf

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805]	PubMed: 39581704
Pathogenesis and drug response of iPSC-derived cardiomyocytes from two Brugada syndrome patients with different Na v1.5-subunit mutations [ J Biomed Res, 2021, 35(5):395-407]	PubMed: 34628405
Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method [ J Pharmacol Toxicol Methods, 2020, 106895]	PubMed: 32629158

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。