R-7050

製品コードS6643 バッチS664301

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C16H8ClF3N4S
分子量 380.77 CAS No. 303997-35-5
Solubility (25°C)* 体外 DMSO 9 mg/mL warmed with 50ºC water bath (23.63 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 R-7050 is a cell permeable TNF-α receptor antagonist and is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.
in vitro

R-7050 has a clear selectivity toward TNFα and to a slightly weaker extent toward the LPA receptor which belongs to a GPCR class over IL-1β, tyrosine kinase, or Fas receptor systems[2].
in vivo

R-7050 attenuates neurovascular injury after intracerebral hemorrhage (ICH) in mice, Up to 2h post-injury administration of R-7050 significantly reduced blood-brain barrier opening and attenuated edema development at 24h post-ICH. Neurological outcomes were also improved over the first three days after injury. In contrast, R-7050 did not reduce hematoma volume[1].

プロトコル(参考用のみ)

動物実験 動物モデル A mouse collagenase model of ICH (based on male CD-1 mice)
投薬量 6–18 mg/kg
投与方法 IP

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Macrophage polarization induces endothelium-to-myofibroblast transition in chronic allograft dysfunction [ Ren Fail, 2023, 45(1):2220418] PubMed: 37288756
Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME [ Elife, 2022, 11e73792] PubMed: 35972780
DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR [ Int J Mol Sci, 2022, 23(24)15522] PubMed: 36555168
DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR [ Int J Mol Sci, 2022, 23(24)15522] PubMed: 36555168
The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons [ J Neuroinflammation, 2021, 18(1):261] PubMed: 34749758
The effect of macrophages polarization on the expression of oxytocin signaling system in enteric neurons [ Research Square, 2021, 10.21203/rs.3.rs-611538/v1] PubMed: None
Fragmentation of cell-free DNA is induced by upper-tract urothelial carcinoma-associated systemic inflammation [ Cancer Sci, 2020, 112(1):168-177] PubMed: 33027843
TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation [ Cell Signal, 2020, 73:109702] PubMed: 32619562

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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