Remodelin hydrobromide

製品コードS7641 バッチS764103

印刷

化学情報

Synonyms

Remodelin HBr

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₅BrN₄S

分子量

363.28

CAS No.

1622921-15-6

Solubility (25°C)*

体外

DMSO

72 mg/mL (198.19 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 Corn oil

2.5mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.
in vitro	Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases. ^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	PC-3 and VCaP cells
	濃度	20 µM
	反応時間	48 h
	実験の流れ	Cells were treated with different concentrations of Remodelin (0, 2, 10, 20, or 40 µM) for 48 h and proliferation was evaluated.
動物実験	動物モデル	Male nude athymic BALB/c nu/nu mice
	投薬量	2 or 20 mg/kg
	投与方法

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration [ Nat Commun, 2024, 15(1):2137]	PubMed: 38459019
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury [ Redox Biol, 2024, 72:103145]	PubMed: 38583415
Targeting the NAT10/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy [ Mol Med, 2024, 30(1):13]	PubMed: 38243170
N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop [ Adv Sci (Weinh), 2023, 10(23):e2300898]	PubMed: 37328448
Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression [ J Exp Clin Cancer Res, 2023, 42(1):9]	PubMed: 36609449
P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma [ Mol Cell Proteomics, 2023, 22(3):100504]	PubMed: 36708875
Inhibition of N-Acetyltransferase 10 Suppresses the Progression of Prostate Cancer through Regulation of DNA Replication [ Int J Mol Sci, 2022, 23(12)6573]	PubMed: 35743017
c-myc-mediated upregulation of NAT10 facilitates tumor development via cell cycle regulation in non-small cell lung cancer [ Med Oncol, 2022, 39(10):140]	PubMed: 35834140
NAT10 as a potential prognostic biomarker and therapeutic target for HNSCC [ Cancer Cell Int, 2021, 21(1):413]	PubMed: 34362389
N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells [ Transl Oncol, 2020, 16;13(8):100783]	PubMed: 32428852

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。