Resiquimod (R-848)

製品コードS8133 バッチS813301

印刷

化学情報

Chemical Structure Synonyms S28463 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C17H22N4O2
分子量 314.38 CAS No. 144875-48-9
Solubility (25°C)* 体外 DMSO 63 mg/mL (200.39 mM)
Ethanol 21 mg/mL warmed with 50ºC water bath (66.79 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2.
in vitro

Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. [1]

Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. [2]

Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs. [3]
in vivo

In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines. [1]

In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling. [4]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Peripheral blood leukocytes
濃度 0.5–2 μg/ml
反応時間 24 h
実験の流れ

Cells were treated with various concentrations of drug.
動物実験 動物モデル Wild-type mice, TLR7-deficient mice, and MyD88-deficient mice
投薬量 50 nmol
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype [ Front Immunol, 2024, 15:1331480] PubMed: 38545103
Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis [ Biology (Basel), 2023, 12(2)318] PubMed: 36829595
Targetable leukemia dependency on noncanonical PI3Kγ signaling [ bioRxiv, 2023, 10.1101/2023.12.15.571909] PubMed: none
Drug-Dependent Morphological Transitions in Spherical and Worm-Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs [ Small, 2022, 18(4):e2103552] PubMed: 34841670
Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment [ Eur J Pharm Biopharm, 2022, S0939-6411(2200306-X)] PubMed: 36549400
Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC [ Biochem J, 2022, 479(20):2195-2216] PubMed: 36098982
Hydrogel-Based Slow Release of a Receptor-Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS-CoV-2 [ Adv Mater, 2021, 33(51):e2104362] PubMed: 34651342
Tumor Activated Cell Penetrating Peptides to Selectively Deliver Immune Modulatory Drugs [ Pharmaceutics, 2021, 13(3)365] PubMed: 33801967
Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2 [ bioRxiv, 2021, 2021.03.31.437792] PubMed: 33821276
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells [ Nat Commun, 2020, 11(1):3521] PubMed: 32665556

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。