Retinoic acid (Tretinoin, Vitamin A acid)

製品コードS1653 バッチS165303

印刷

化学情報

Synonyms

All-trans Retinoic Acid, ATRA, Vitamin A acid,NSC 122758

Storage
(From the date of receipt)

3 years -20°C(in the dark) powder

化学式

C₂₀H₂₈O₂

分子量

300.4

CAS No.

302-79-4

Solubility (25°C)*

体外

DMSO

60 mg/mL (199.73 mM)

Ethanol

7 mg/mL (23.3 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.Tretinoin (NSC 122758) can be used to induce animal models of Osteoporosis.
in vitro	Retinoic acid (Tretinoin, Vitamin A acid) prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Its incubation leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. This compound also upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts.
in vivo	Retinoic acid (Tretinoin, Vitamin A acid) has been shown to reduce renal cortex protein content by 30% in treated old male Fischer 344 rats compared to controls, an effect potentially mediated through inhibition of tumor necrosis factor-beta1 and osteopontin expression. It also prevents major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. When combined with imiquimod, this compound leads to tattoo fading and moderate pigment clearance on histopathology in guinea pigs. Additionally, it increases fibroblastic proliferation in skin incisions made in CD-1 mice, though collagen production is diminished.

製品説明

Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.Tretinoin (NSC 122758) can be used to induce animal models of Osteoporosis.

in vitro

Retinoic acid (Tretinoin, Vitamin A acid) prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Its incubation leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis.

This compound also upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts.

in vivo

Retinoic acid (Tretinoin, Vitamin A acid) has been shown to reduce renal cortex protein content by 30% in treated old male Fischer 344 rats compared to controls, an effect potentially mediated through inhibition of tumor necrosis factor-beta1 and osteopontin expression.

It also prevents major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy.

When combined with imiquimod, this compound leads to tattoo fading and moderate pigment clearance on histopathology in guinea pigs.

Additionally, it increases fibroblastic proliferation in skin incisions made in CD-1 mice, though collagen production is diminished.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BE2C cells
	濃度	5 μM
	反応時間	6 days
	実験の流れ	Retinoic acid (Tretinoin, Vitamin A acid) was used to treat cells at the indicated concentration for 6 days.
動物実験	動物モデル	Female Skh-hairless-1 albino mice
	投薬量	0.05%
	投与方法	Dorsal application

参考

https://pubmed.ncbi.nlm.nih.gov/10086995/
https://pubmed.ncbi.nlm.nih.gov/14756522/
https://pubmed.ncbi.nlm.nih.gov/8106754/

https://pubmed.ncbi.nlm.nih.gov/11998793/
https://pubmed.ncbi.nlm.nih.gov/15793506/
https://pubmed.ncbi.nlm.nih.gov/34669465/
https://pubmed.ncbi.nlm.nih.gov/7706770/
https://pubmed.ncbi.nlm.nih.gov/27078158/
https://pubmed.ncbi.nlm.nih.gov/12963727/
https://pubmed.ncbi.nlm.nih.gov/1323127/

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カスタマーフィードバック

: Data from [Data independently produced by , , Cell, 2018, 175(5):1244-1258]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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