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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C12H22N6O6 |
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分子量 | 346.34 | CAS No. | 99896-85-2 | |
Solubility (25°C)* | 体外 | DMSO | 69 mg/mL (199.22 mM) | |
Water | 69 mg/mL (199.22 mM) | |||
Ethanol | 69 mg/mL (199.22 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. |
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in vitro | The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer. [1] RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. [2] The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. [3] In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. [4] |
細胞アッセイ | 細胞株 | HLE cell line |
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濃度 | 0.1, 0.3, 1.0 and 2.0 mg/ml | |
反応時間 | 90 min | |
実験の流れ | The cells were seeded at approximately 2.6 × 104 /well on each ECM-coated 24-well plate in the medium containing the monotype of GRGDSP RGD peptide at 0 (control), 0.1, 0.3, 1.0 and 2.0 mg/ml. After 90 min of incubation, the floating cells were removed by washing twice with Ca 2+ -Mg 2+ -free phosphate-buffered saline. Then the attached cells were dissociated with trypsin-EDTA solution. The number of cells attached at each concentration of peptide was counted using a hemocytometer. |
Data from [Data independently produced by , , Int J Nanomedicine, 2018, 13:7657-7667]
Data from [Data independently produced by , , J Biol Chem, 2016, 291(28):14815-25.]
Data from [Data independently produced by , , Neuroscience, 2019, 396:187-199]
Dendritic cells overcome Cre/Lox induced gene deficiency by siphoning cytosolic material from surrounding cells [ iScience, 2024, 27(3):109119] | PubMed: 38384841 |
Multimodal characterization of murine gastruloid development [ Cell Stem Cell, 2023, 30(6):867-884.e11] | PubMed: 37209681 |
Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion [ Biosens Bioelectron, 2023, 226:115113] | PubMed: 36764127 |
Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp [ Mbio, 2023, Vol. 14, No. 2] | PubMed: None |
Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp [ mBio, 2023, e0291922.] | PubMed: 36779788 |
Structural Optimization and Interaction Study of a DNA Aptamer to L1 Cell Adhesion Molecule [ Int J Mol Sci, 2023, 24(10)8612] | PubMed: 37239955 |
Crosstalk between integrin/FAK and Crk/Vps25 governs invasion of bovine mammary epithelial cells by S. agalactiae [ iScience, 2023, 26(10):107884] | PubMed: 37766995 |
Sandwich Culture Platforms to Investigate the Roles of Stiffness Gradients and Cell-Matrix Adhesions in Cancer Cell Migration [ Cancers (Basel), 2023, 15(6)1729] | PubMed: 36980615 |
Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2 [ Front Oncol, 2023, 13:1142907] | PubMed: 37091157 |
Dendritic Cells Overcome Cre/Lox Induced Gene Deficiency by Siphoning Material From Neighboring Cells Using Intracellular Monitoring-a Novel Mechanism of Antigen Acquisition [ bioRxiv, 2023, 2023.07.22.550169] | PubMed: 37546718 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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