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Synonyms | Vistamycin Sulfate,Landamycine | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C17H34N4O10.H2SO4 |
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分子量 | 552.55 | CAS No. | 53797-35-6 | |
Solubility (25°C)* | 体外 | Water | 100 mg/mL (180.97 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Ribostamycin Sulfate(Vistamycin Sulfate,Landamycine) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus. |
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in vitro | Ribostamycin inhibits the chaperone activity of protein disulfide isomerase (PDI), but it does not inhibit the isomerase activity, a 100:1 molar ratio of ribostamycin to PDI is almost sufficient to completely inhibit the chaperone activity of PDI. Ribostamycin binds to purified bovine PDI with KD of 0.319 mM. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes. [1] Ribostamycin exhibits antimicrobial activity against B. burgdorferi isolates with MIC of 18.7 mg/L. [2] Ribostamycin (16 mcg/mL) inhibits 100% of the P. stagnora strains and 95% of the P. wickerhamii strains, while Ribostamycin (16 mcg/mL) inhibits 100% of the P. zopfii strains. [3] |
in vivo | Ribostamycin (400 mg/kg/day) shows the weakest ototoxicity against the cochlea and vestibular organs in guinea pigs. Ribostamycin (400 mg/kg/day), causing the weakest ototoxicity, shows a low drug concentration in the inner ear fluid of of guinea pigs. [4] |
Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury. [ PLoS Pathog, 2020, 16;16(3):e1008341] | PubMed: 32176725 |
Targeting the nsp2 Cysteine Protease of Chikungunya Virus Using FDA Approved Library and Selected Cysteine Protease Inhibitors. [ Pathogens, 2019, 8(3)] | PubMed: 31443266 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。