RIPA-56

製品コードS6511 バッチS651101

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₃H₁₉NO₂
	分子量	221.30	CAS No.	1956370-21-0
Solubility (25°C)*	体外	DMSO	44 mg/mL (198.82 mM)
		Ethanol	44 mg/mL (198.82 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.
in vitro	RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM. It showed no inhibition of RIP3 kinase activity at a 10 µM concentration. RIPA-56 does not inhibit IDO activity at a concentration of 200 µM, which represents an estimated 10,000-fold selectivity window based on the RIP1 ADP-Glo activity of 13 nM^[1].
in vivo	RIPA-56 has an impressive PK profile in mice, with a 3.1 h half-life, 22% oral bioavailability (PO), and 100% bioavailability from intraperitoneal injection (IP). RIPA-56 has great ability in transporting across blood brain barrier. In the SIRS mice disease model, RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage^[1].

プロトコル(参考用のみ)

参考

[1] Ren Y, et al. J Med Chem. 2017, 60(3):972-986.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

TGR5 overexpression mediated by the inhibition of transcription factor SOX9 protects against hypoxia-/reoxygenation-induced injury in hippocampal neurons by activating Nrf2/HO-1 signaling [ Ann Transl Med, 2022, 10(22):1245]	PubMed: 36544646
SBP-0636457, a Novel Smac Mimetic, Cooperates with Doxorubicin to Induce Necroptosis in Breast Cancer Cells during Apoptosis Blockage [ J Oncol, 2022, 2022:2390078]	PubMed: 35859663
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. [ Cancer Cell Int, 2020, 30;20:36]	PubMed: 32021565
Prmt4-mediated methylation of NF-κB is critical for neural differentiation of embryonic stem cells. [ Biochem Biophys Res Commun, 2020, 10.1016/j.bbrc.2020.02.072]	PubMed: 32070496

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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