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Synonyms | F 440 | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C14H9N4NaO5 |
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分子量 | 336.23 | CAS No. | 14663-23-1 | |
Solubility (25°C)* | 体外 | DMSO | 9 mg/mL warmed with 50ºC water bath (26.76 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
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in vitro | Treatment with a mixture of Thaps. and dantrolene during optogenetic stimulation (OS) of Schwann cells (SCs) significantly decreases the percentage of MBP-expressing SCs and, importantly, reduces the percentage of MBP-expressing SCs. Mixture of Thaps. and dantrolene decreases drastically the ΔF/F value in SCs.[1] |
in vivo | Dantrolene administration decreases plasma GLuc-SERCaMP activity and endogenous SERCaMP activity when compared to vehicle during ad lib high fat diet. Rats administered dantrolene gains less weight compared to vehicle treated rats, and have less caloric intake. |
細胞アッセイ | 細胞株 | Schwann cells |
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濃度 | 600 nM | |
反応時間 | 4 h | |
実験の流れ | Thaps. + Dantrolene (600 nM, a ryanodine receptor antagonist) for 4 h prior to examining the intracellular Ca2+ levels of SCs. Representative inverted images of BABTA-1 AM fluorescence signals showing the intracellular Ca2+ on SCs. |
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動物実験 | 動物モデル | High fat diet rats |
投薬量 | 15mg/kg | |
投与方法 | i.p. |
Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLoS Pathog, 2023, 19(3):e1011295] | PubMed: 36972295 |
Heliox Preconditioning Exerts Neuroprotective Effects on Neonatal Ischemia/Hypoxia Injury by Inhibiting Necroptosis Induced by Ca2+ Elevation [ Transl Stroke Res, 2022, 10.1007/s12975-022-01021-8] | PubMed: 35445968 |
Reactive Oxygen Species Regulate Endoplasmic Reticulum Stress and ER-Mitochondrial Ca2+ Crosstalk to Promote Programmed Necrosis of Rat Nucleus Pulposus Cells under Compression [ Oxid Med Cell Longev, 2021, 2021:8810698] | PubMed: 33815661 |
Optogenetic stimulation promotes Schwann cell proliferation, differentiation, and myelination in vitro. [ Sci Rep, 2019, 9(1):3487] | PubMed: 30837563 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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