MIK665 (S64315)

製品コードS8836 バッチS883602

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₄₇H₄₄ClFN₆O₆S
	分子量	875.41	CAS No.	1799631-75-6
Solubility (25°C)*	体外	DMSO	100 mg/mL (114.23 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	MIK665 (S64315)は、誘導性骨髄性白血病細胞分化タンパク質Mcl-1の阻害剤であり、Ki値は1.2 nMで、アポトーシス促進作用および抗腫瘍作用の可能性があります。
in vitro	S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1.
in vivo	S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	H929 cells
	濃度	26 pM (Ki)
	反応時間	6 h
	実験の流れ	H929 cells were treated for 6 h with increasing concentration of S64315.
動物実験	動物モデル	Female CB-17 SCID mice
	投薬量	12.5 mg/kg
	投与方法	i.v.

参考

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205821/
https://pubmed.ncbi.nlm.nih.gov/33146521/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [ Cancer Biology & Therapy, November 14, 2024, 2427374]	PubMed: 39540618
Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models [ Blood Advances, March 10, 2020, 819-829]
Novel PI3kδ inhibitor roginolisib synergizes with venetoclax in hematologic malignancies [ Haematologica, June 19, 2025, 2974-2985]	PubMed: 40534489
MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells [ Cell Death & Disease, June 08, 2020, 443]	PubMed: 32513939
Inhibition of BCL-2 and MCL-1 disrupts mitochondrial respiration and overcomes radioresistance in choroidal melanoma [ Biochem Biophys Res Commun, 2025, 784:152650]	PubMed: 40983007
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy [ Nat Commun, 2024, 15(1):1581]	PubMed: 38383524
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy [ Nature Communications, 2024, 1581]	PubMed: 38383524
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [ Cancer Biology & Therapy, 2024, 2427374]	PubMed: 39540618
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [ Cancer Biol Ther, 2024, 25(1):2427374]	PubMed: 39540618
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176]	PubMed: 37773750

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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