Sarilumab (anti-IL-6Rα)

製品コード：A2011         Batch: A201101

印刷

Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

製品説明

CAS No. 1189541-98-7
Formulation PBS buffer, pH 7.2
Isotype Human IgG1
Source CHO cells
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping Shipped under low temperature conditions
Purity 98.05%
Protein concentration 5.0 mg/ml
Endotoxin Level ≤1 EU/mg

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Development of a Genetically Modified Lactococcus lactis Strain that Produces a Single-Chain Variable Fragment Targeting Interleukin-6 Receptor α to Suppress Serum Amyloid A [ Curr Microbiol, 2025, 82(11):522] PubMed: 41003755
Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs [ Biomed Pharmacother, 2024, 173:116357] PubMed: 38479179
Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis [ Front Immunol, 2024, 15:1470907] PubMed: 39877352
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System [ Small, 2023, 19(34):e2203725] PubMed: 37104853
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System [ Small, 2023, e2203725.] PubMed: 37104853
Induction of IL-6Rα by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance in hepatocellular carcinoma [ Cancer Lett, 2022, 524:161-171] PubMed: 34687791
Human mesenchymal stem cells-derived conditioned medium inhibits hypoxia-induced death of neonatal porcine islets by inducing autophagy. [ Xenotransplantation, 2019,  doi: 10] PubMed: 31578787

人間や獣医の診断であるか治療的な使用のためにでない。