SB-3CT

製品コードS7430 バッチS743001

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₄O₃S₂

分子量

306.40

CAS No.

292605-14-2

Solubility (25°C)*

体外

DMSO

61 mg/mL (199.08 mM)

Ethanol (warmed with 50ºC water bath)

10 mg/mL (32.63 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SB-3CTは、MMP-2およびMMP-9に対するK_iがそれぞれ13.9 nMおよび600 nMである、効果的で選択的なゼラチナーゼ阻害剤です。
in vitro	SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro.
in vivo	In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. This compound (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, this chemical counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion.

製品説明

SB-3CTは、MMP-2およびMMP-9に対するK_iがそれぞれ13.9 nMおよび600 nMである、効果的で選択的なゼラチナーゼ阻害剤です。

in vitro

SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro.

in vivo

In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice.

This compound (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model.

In a mouse model of embolus-induced “permanent” focal cerebral ischemia, this chemical counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion.

プロトコル(参考用のみ)

キナーゼアッセイ	Fluorescence enzymatic activity assays
キナーゼアッセイ	The enzymatic activity of MMP-2, MMP-9 and MMP-7 is monitored with the fluorescence quenched substrate MOCAcPLGLA2pr(Dnp)-AR-NH2. Fluorescence is measure with a PTI spectrofluorometer. The cuvette compartment is thermostated at 25 ℃ 。
細胞アッセイ	細胞株	HCC cells
	濃度	0.1 μM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentration of SB-3CT for 24 h.
動物実験	動物モデル	Mouse L-CI.5s T-cell lymphoma model
	投薬量	50 mg/kg/d
	投与方法	i.p.

参考

http://pubs.acs.org/doi/pdf/10.1021/ja001461n
https://pubmed.ncbi.nlm.nih.gov/15867341/
https://pubmed.ncbi.nlm.nih.gov/16381009/

https://pubmed.ncbi.nlm.nih.gov/22587708/
https://pubmed.ncbi.nlm.nih.gov/35406401/

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カスタマーフィードバック

: Data from [Data independently produced by , , Cell Physiol Biochem, 2017, 44(6):2281-2295]

: Data from [Data independently produced by , , Mol Nutr Food Res, 2018, doi:10.1002/mnfr.201700969]

: Data from [Data independently produced by , , Neuropharmacology, 2017, 118:157-166]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

High matrix metalloproteinase-2 expression predicts poor prognosis of colon adenocarcinoma and is associated with PD-L1 expression and lymphocyte infiltration [ PeerJ, 2025, 13:e19550]	PubMed: 40611940
An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity [ Pharmacol Res, 2023, 190:106720]	PubMed: 36893823
COL4A3 Mutation Induced Podocyte Apoptosis by Dysregulation of NADPH Oxidase 4 and MMP-2 [ Kidney Int Rep, 2023, 8(9):1864-1874]	PubMed: 37705901
Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice [ Brain Res Bull, 2023, 204:110810]	PubMed: 37939860
Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson's Disease Mouse Model [ Int J Mol Sci, 2022, 23(5)2793]	PubMed: 35269933
MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice [ J Neurosci, 2022, 42(1):16-32]	PubMed: 34764155
Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer-Targeted Therapies [ Cancers (Basel), 2022, 14(7)1630]	PubMed: 35406401
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice [ BMC Pulm Med, 2022, 22(1):230]	PubMed: 35705936
Rotenone impairs learning and memory in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis [ Chemosphere, 2021, S0045-6535(21)03454-8]	PubMed: 34822863
GSK-3α/β Activity Negatively Regulates MMP-1/9 Expression to Suppress Mycobacterium tuberculosis Infection [ Front Immunol, 2021, 12:752466]	PubMed: 35095838

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。