受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
||||
化学式 | C31H33N3O5 |
||||||
分子量 | 527.61 | CAS No. | 489415-96-5 | ||||
Solubility (25°C)* | 体外 | DMSO | 50 mg/mL (94.76 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
|
||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist. |
---|---|
in vitro | In HepG2 cells, SBC-115076 increases the uptake of Fluorescent Dil-LDL. [1] |
in vivo | In mice that are fed high fat diet, SBC-115076 (8 mg/kg) lowers cholesterol levels by 32%. [1] |
細胞アッセイ | 細胞株 | THP-1 cells |
---|---|---|
濃度 | 20 μM | |
反応時間 | 24 h | |
実験の流れ | Cells were treated with indicated concentration of drug for 24 h. |
|
動物実験 | 動物モデル | Female Wistar rats |
投薬量 | 4 mg/kg | |
投与方法 | s.c. |
|
Fumarate Hydratase Enhances the Therapeutic Effect of PD-1 Antibody in Colorectal Cancer by Regulating PCSK9 [ Cancers (Basel), 2024, 16(4)713] | PubMed: 38398104 |
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice [ Front Med (Lausanne), 2024, 11:1284199] | PubMed: 38596793 |
Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoE-/- Mice [ Front Cardiovasc Med, 2021, 8:746989] | PubMed: 34660746 |
A proprotein convertase subtilisin/kexin type 9 inhibitor provides comparable efficacy with lower detriment than statins on mitochondria of oxidative muscle of obese estrogen-deprived rats [ Menopause, 2020, 27(10):1155-1166] | PubMed: 32576799 |
Effect of aerobic exercise on blood lipid of hyperlipidemia rats and its mechanism [ Journal of Second Military Medical University, 2019, 40(4): 412-419] | PubMed: None |
A New Strategy for Rapidly Screening Natural Inhibitors Targeting the PCSK9/LDLR Interaction In Vitro. [ Molecules, 2018, 23(9)] | PubMed: 30235833 |
Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus [ J Virol, 2017, 91(16)e00461-17] | PubMed: 28566376 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。